Dual-Mode Avocado-like All-Iron Nanoplatform for Enhanced T1/T2 MRI-Guided Cancer Theranostic Therapy
Dual-Mode Avocado-like All-Iron Nanoplatform for Enhanced T1/T2 MRI-Guided Cancer Theranostic Therapy
复制标题
用于增强 T1/T2 MRI 引导癌症治疗的双模式类牛油果全铁纳米平台
DOI：
10.1021/acs.nanolett.0c00817
复制
发表时间：
2020-07-08
期刊：
影响因子：
10.8
通讯作者：
Sun, Minjie
中科院分区：
文献类型：
--
作者：
Li, Jing;Li, Xincong;Sun, Minjie
开发可治疗癌症的T-1/T-2双模磁共振造影剂是个性化精确医学的一个诱人的前景。不幸的是，传统的造影剂可能会受到毒性的影响，并且缺乏治疗癌症的能力。一种具有光热和药物输送能力的全铁T-1/T-2磁共振成像剂将克服这些问题。本文研制了一种基于Fe-TA配位网络(CNMN)的类牛油果Fe3+/Fe2O3双模造影剂。这种材料具有合适的纵向和横向松弛系数。此外，Fe-TA的强生热特性赋予了CNMN作为一种有效的光热剂的能力。此外，CNMN还可以作为化疗药物阿霉素(DOX)的有效传递平台，实现高效的化疗-光热联合治疗。这项工作证明了可靠的T-1-T-2MRI引导的化疗-光热治疗安全有效的临床应用。
Development of T-1/T-2 dual-mode MRI contrast agents that can also treat cancer is an attractive prospect for personalized precision medicine. Unfortunately, conventional contrast agents can suffer from toxicity and lack any ability to treat cancer. An all-iron T-1/T-2 MR imaging agent with photothermal and drug delivery capability would overcome these issues. Here, an avocado-like Fe3+/Fe2O3 composed T-1-T-2 dual-mode contrast agent based on Fe-TA coordination network (CNMN) is developed. This material possesses suitable longitudinal and transverse relaxation coefficients. Moreover, the strong heat generation property of Fe-TA endows CNMN with the capability to act as a potent photothermal agent. Furthermore, CNMN can also act as an effective delivery platform for the chemotherapeutic drug doxorubicin (DOX) to achieve high effective chemo-photothermal combination therapy. The work demonstrates reliable T-1-T-2 MRI-guided chemo-photothermal therapy for safe and effective clinical application.