Abundance of microRNA target motifs in the 3′-UTRs of 20527 human genes
Abundance of microRNA target motifs in the 3′-UTRs of 20527 human genes
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DOI：
10.1016/j.febslet.2007.03.066
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发表时间：
2007-05-01
期刊：
影响因子：
3.5
通讯作者：
Kuriyama, Shigeki
中科院分区：
文献类型：
--
作者：
Iwama, Hisakazu;Masaki, Tsutomu;Kuriyama, Shigeki
一种机制，选择性回避，提出了microRNA（miRNA）靶位点在与miRNA同时表达的基因的3 '-UTR中被选择性地耗尽。如果这种机制是普遍存在的，则3 '-UTR中的靶基序出现将减少。为了验证这一假设，我们检测了20527个人类蛋白质编码基因的3 '-和5'-UTR中miRNA靶基序的出现。结果表明，miRNA靶基序比非靶基序出现频率高，且在3 '-UTR中富集。这种富集在一组2525个与miR-124 a共表达的基因中相对减少，但仍然保持在高水平，这表明miRNA靶基序受到一些其他因素的促进，这些因素超过了选择性回避的影响。(C)2007年欧洲生物化学学会联合会。Elsevier B. V.出版，保留所有权利。
A mechanism, selective avoidance, proposes that microRNA (miRNA) target sites are selectively depleted in the 3'-UTRs of genes expressed at the same time and place as a miRNA. If this mechanism is ubiquitous, the target motif occurrences in the 3'-UTRs would be decreased. To test this hypothesis, we examined miRNA target motif occurrences in the 3'- and 5'-UTRs of 20527 human protein-coding genes. The results revealed that miRNA target motifs appeared more frequently than non-target motifs and were enriched in the 3'-UTRs. This enrichment was relatively reduced in a set of 2525 genes coexpressed with miR-124a in the prefrontal cortex, but still remained at a high level, suggesting that miRNA target motifs are fostered by some other factors that surpass the influence of selective avoidance. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.