Subthalamic nucleus neurons are synchronized to primary motor cortex local field potentials in Parkinson's disease.
Subthalamic nucleus neurons are synchronized to primary motor cortex local field potentials in Parkinson's disease.
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DOI：
10.1523/jneurosci.4676-12.2013
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发表时间：
2013-04-24
期刊：
影响因子：
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通讯作者：
Starr PA
中科院分区：
文献类型：
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作者：
Shimamoto SA;Ryapolova-Webb ES;Ostrem JL;Galifianakis NB;Miller KJ;Starr PA
在帕金森病（PD），纹状体多巴胺去神经导致下游基底神经节核的单个单位活动的异常级联，包括增加的放电率，改变的放电模式，和增加的振荡活动。然而，这些异常对皮质功能的影响知之甚少。在这里，在接受深部脑刺激器植入手术的人类中，我们利用硬膜下皮质电描记术结合丘脑底核（STN）单单位记录的新技术来研究毫秒时间尺度下的基底节-皮质相互作用。我们发现，在帕金森病患者中，ESTA尖峰与初级运动皮层（M1）局部场电位同步，有两种不同的模式：第一，ESTA尖峰与M1节律在θ，α或β（4-30 Hz）波段相位同步。第二，在宽光谱范围（50-200 Hz）内，M1的伽马活动与M1的尖峰同步。M1中的棘波同步伽马活动的幅度本身由较低频率节律的相位进行节律性调制（相位-幅度耦合），使得相位同步伽马活动的“波”先于棘波的出现。我们显示疾病的特异性，这些现象在PD中，通过比较与STN-M1配对记录在一组患者与不同的疾病，原发性颅颈肌张力障碍。我们的研究结果支持PD中基底节-丘脑皮质回路的模型，其中初级运动皮层中的γ活动由低频节律的相位调制，驱动单位放电。
In Parkinson’s disease (PD), striatal dopamine denervation results in a cascade of abnormalities in the single unit activity of downstream basal ganglia nuclei that include increased firing rate, altered firing patterns, and increased oscillatory activity. However, the effects of these abnormalities on cortical function are poorly understood. Here, in humans undergoing deep brain stimulator implantation surgery, we utilize the novel technique of subdural electrocorticography in combination with subthalamic nucleus (STN) single unit recording to study basal ganglia-cortex interactions at the millisecond time scale. We show that in patients with PD, STN spiking is synchronized with primary motor cortex (M1) local field potentials in two distinct patterns: First, STN spikes are phase-synchronized with M1 rhythms in the theta, alpha, or beta (4-30 Hz) bands. Second, STN spikes are synchronized with M1 gamma activity over a broad spectral range (50-200 Hz). The amplitude of STN spike-synchronized gamma activity in M1 is itself rhythmically modulated by the phase of a lower frequency rhythm (phase-amplitude coupling), such that “waves” of phase-synchronized gamma activity precede the occurrence of STN spikes. We show the disease specificity of these phenomena in PD, by comparison with STN-M1 paired recordings performed in a group of patients with a different disorder, primary cranio-cervical dystonia. Our findings support a model of the basal ganglia-thalamocortical loop in PD in which gamma activity in primary motor cortex, modulated by the phase of low frequency rhythms, drives STN unit discharge.