Default mode network connectivity and cognition in the aging brain: the effects of age, sex, and APOE genotype.
Default mode network connectivity and cognition in the aging brain: the effects of age, sex, and APOE genotype.
复制标题
DOI：
10.1016/j.neurobiolaging.2021.03.013
复制
发表时间：
2021-04
影响因子：
4.2
通讯作者：
A. Shafer;L. Beason-Held;Y. An;Owen A. Williams;Yuankai Huo;B. Landman;B. Caffo;S. Resnick
中科院分区：
文献类型：
--
作者：
A. Shafer;L. Beason-Held;Y. An;Owen A. Williams;Yuankai Huo;B. Landman;B. Caffo;S. Resnick
默认模式网络（DMN）与显示早期阿尔茨海默病（AD）病理的区域重叠。年龄、性别和载脂蛋白E β 4是发展为AD的主要危险因素。这些危险因素如何相互作用，影响DMN的连接和连接性认知关系的损害发生前仍然未知。在这里，我们在475名认知正常的成年人中研究了这些问题，目标是总DMN连接，其神经元相关网络（acDMN）和DMN-海马组件。有四个主要发现。第一，在α 3纯合子组中，随着年龄的增长，观察到较低的DMN和acDMN连接。第二，性别和1004改变了年龄与DMN和海马连接性之间的关系，1004与1003男性显示出持续或更高的连接性与年龄。第三，在2003年组中，年龄和性别改变了连接-认知关系，年龄最大的参与者由于性别而具有最大的差异模式。第四，连接性较低的104个载波的认知表现较差。总之，我们的研究结果表明，AD的三个主要危险因素相互作用，影响大脑功能和功能认知关系。
The default mode network (DMN) overlaps with regions showing early Alzheimer's Disease (AD) pathology. Age, sex, and apolipoprotein E ɛ4 are the predominant risk factors for developing AD. How these risk factors interact to influence DMN connectivity and connectivity-cognition relationships before the onset of impairment remains unknown. Here, we examined these issues in 475 cognitively normal adults, targeting total DMN connectivity, its anticorrelated network (acDMN), and the DMN-hippocampal component. There were four main findings. First, in the ɛ3 homozygous group, lower DMN and acDMN connectivity was observed with age. Second, sex and ɛ4 modified the relationship between age and connectivity for the DMN and hippocampus with ɛ4 vs. ɛ3 males showing sustained or higher connectivity with age. Third, in the ɛ3 group, age and sex modified connectivity-cognition relationships with the oldest participants having the most differential patterns due to sex. Fourth, ɛ4 carriers with lower connectivity had poorer cognitive performance. Taken together, our results show the three predominant risk factors for AD interact to influence brain function and function-cognition relationships.