Hooked on benzodiazepines: GABAA receptor subtypes and addiction.
Hooked on benzodiazepines: GABAA receptor subtypes and addiction.
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DOI：
10.1016/j.tins.2011.01.004
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发表时间：
2011-04
影响因子：
15.9
通讯作者：
Luescher, Christian
中科院分区：
文献类型：
--
作者：
Tan, Kelly R.;Rudolph, Uwe;Luescher, Christian
Benzodiazepines are widely used clinically to treat anxiety and insomnia. They also induce muscle relaxation, control epileptic seizures, and can provoke amnesia. Moreover, benzodiazepines are often abused after chronic clinical treatment but also for recreational purposes. Within weeks, tolerance to the pharmacological effects can develop, in addition to dependence and even addiction in vulnerable individuals. Here, we review recent observations from animal models regarding the cellular and molecular basis that may underlie the addictive properties of benzodiazepines. These data reveal how benzodiazepines, acting through specific GABAA receptor subtypes, activate midbrain dopamine neurons and how this may hijack the mesolimbic reward system. Such findings have important implications for the future design of benzodiazepines with reduced or even absent addiction liability.
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影响因子：
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