Prednisolone in the treatment of adrenal insufficiency: A re-evaluation of relative potency
Prednisolone in the treatment of adrenal insufficiency: A re-evaluation of relative potency
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DOI：
10.1067/s0022-3476(03)00294-4
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发表时间：
2003-09-01
影响因子：
5.1
通讯作者：
Polychronakos, C
中科院分区：
文献类型：
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作者：
Punthakee, Z;Legault, L;Polychronakos, C
泼尼松龙相对于其他类固醇具有未知的生长抑制作用。我们回顾性研究了9名儿童（6名先天性肾上腺皮质增生，CAH）在转换为泼尼松龙（剂量比，1：5）后接受氢化可的松替代治疗。CAH患者的生长速度和17-OHP显著降低。减少剂量可逆转这些效应。大致上，泼尼松龙与氢化可的松的生长抑制相对效力为15：1。
Prednisolone has unknown growth-suppressing effects relative to other steroids. We retrospectively studied 9 children (6 with congenital adrenal hyperplasia, CAH) receiving hydrocortisone replacement after switching to prednisolone (dose ratio, 1:5). Growth velocity and, in patients with CAH, 17-OHP decreased significantly. Dose reduction reversed these effects. Roughly, growth suppression relative potency for prednisolone:hydrocortisone was 15:1.