From epinephrine to cyclic AMP.
From epinephrine to cyclic AMP.
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从肾上腺素到环AMP。
DOI：
10.1126/science.2841758
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Levitzki,A
中科院分区：
文献类型：
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作者：
Levitzki,A
儿茶酚胺与β-肾上腺素能受体的结合导致腺苷酸环化酶的激活和细胞内腺苷3′，5′-单磷酸腺苷（cAMP）的形成。在过去的20年里，人们对细胞表面受体位点的激素结合到膜内层cAMP合成的过程进行了深入的研究。该系统的信号转导涉及β-肾上腺素能受体与鸟嘌呤核苷酸结合蛋白（Gs）和腺苷酸环化酶催化剂(C)的顺序相互作用。本文讨论了受体通过Gsto C进行信号转导的机制，以及腺苷酸环化酶抑制G蛋白Gi的作用。
Binding of catecholamines to the β-adrenergic receptor results in the activation of adenylate cyclase and the intracellular formation of adenosine 3′,5′-monophosphate (cAMP). In the past 20 years the events that lead from hormone binding at the cell surface receptor site to the synthesis of cAMP at the inner layer of the membrane have been intensively studied. Signal transduction in this system involves the sequential interaction of the β-adrenergic receptor with the guanine nucleotide-binding protein (Gs) and the adenylate cyclase catalyst (C). The mechanism of signal transduction from the receptor through Gsto C, as well as the role of the adenylate cyclase inhibitory G protein Gi, is discussed.