Arsenic trioxide and ascorbic acid: synergy with potential implications for the treatment of acute myeloid leukaemia?
Arsenic trioxide and ascorbic acid: synergy with potential implications for the treatment of acute myeloid leukaemia?
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DOI：
10.1046/j.1365-2141.2001.02608.x
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发表时间：
2001-03-01
影响因子：
6.5
通讯作者：
Gisslinger, H
中科院分区：
文献类型：
--
作者：
Bachleitner-Hofmann, T;Gisslinger, B;Gisslinger, H
三氧化二砷。（As 2 O3）通过诱导细胞凋亡在高比例的急性早幼粒细胞白血病（APL）患者中诱导缓解。初步报告表明，As 2 O3的凋亡作用不是APL特异性的，但也可以在非APL急性髓性白血病（AML）细胞中观察到，尽管这些细胞不如APL细胞敏感，抗坏血酸最近被证明可以增强As 2 O3的凋亡作用。因此，我们评估了联合As 2 O3/抗坏血酸治疗AML的各种临床样本。我们的研究结果表明，As 2 O3和抗坏血酸的显着协同作用，这表明As 2 O3/抗坏血酸联合治疗AML患者的未来可能的作用。
Arsenic trioxide. (As2O3) induces remission in a high proportion of patients with acute promyelocytic leukaemia (APL) via induction of apoptosis. Preliminary reports suggest that the apoptotic effect of As2O3 is not specific for APL but can also be observed in non-APL acute myeloid leukaemia (AML) cells, although these are less sensitive than APL cells, Ascorbic acid has recently been demonstrated to enhance the apoptotic effect of As2O3. We have therefore evaluated combined As2O3/ascorbic acid treatment in various clinical samples of AML. Our results indicate a significant synergistic effect of As2O3 and ascorbic acid, suggesting a possible future role of As2O3/ascorbic acid combination therapy in patients with AML.