HDAC signaling in neuronal development and axon regeneration.
HDAC signaling in neuronal development and axon regeneration.
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DOI：
10.1016/j.conb.2014.03.008
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发表时间：
2014-08
影响因子：
5.7
通讯作者：
Cavalli V
中科院分区：
文献类型：
--
作者：
Cho Y;Cavalli V
神经系统的发育和修复需要大量特定基因的协调表达。组蛋白的表观遗传修饰代表了神经元调节转录反应和适应环境线索的基本原则。染色质修饰酶组蛋白乙酰基转移酶（HAT）和组蛋白脱乙酰基酶（HDAC）对组蛋白的翻译后修饰在神经元发育过程中塑造染色质以调节转录谱。最近的观察还指出组蛋白乙酰化和去乙酰化在神经元对损伤的反应中起关键作用。虽然大多数已知HDAC通过其脱乙酰酶活性及其与辅阻遏物的相互作用来减弱转录，但这些酶也存在于细胞质中，在细胞质中它们通过调节不同蛋白质的功能而显示转录非依赖性活性。在这里，我们讨论了最近的研究，超越了传统的HDAC抑制剂的使用，并已开始剖析个别HDAC亚型在神经元发育和损伤后修复的作用。
The development and repair of the nervous system requires the coordinated expression of a large number of specific genes. Epigenetic modifications of histones represent an essential principle by which neurons regulate transcriptional responses and adapt to environmental cues. The post-translational modification of histones by chromatin-modifying enzymes histone acetyltransferases (HATs) and histone deacetylases (HDACs) shapes chromatin to adjust transcriptional profiles during neuronal development. Recent observations also point to a critical role for histone acetylation and deacetylation in the response of neurons to injury. While HDACs are mostly known to attenuate transcription through their deacetylase activity and their interaction with co-repressors, these enzymes are also found in the cytoplasm where they display transcription-independent activities by regulating the function of diverse proteins. Here we discuss recent studies that go beyond the traditional use of HDAC inhibitors and have begun to dissect the roles of individual HDAC isoforms in neuronal development and repair after injury.
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影响因子：
64.8
作者：
Hubbert, C;Guardiola, A;Yao, TP
通讯作者：
Yao, TP
影响因子：
16.6
作者：
Ageta-Ishihara, Natsumi;Miyata, Takaki;Ohshima, Chika;Watanabe, Masahiko;Sato, Yoshikatsu;Hamamura, Yuki;Higashiyama, Tetsuya;Mazitschek, Ralph;Bito, Haruhiko;Kinoshita, Makoto
通讯作者：
Kinoshita, Makoto
影响因子：
64.5
作者：
Cho Y;Sloutsky R;Naegle KM;Cavalli V
通讯作者：
Cavalli V
影响因子：
4.7
作者：
Chawla, S;Vanhoutte, P;Bading, H
通讯作者：
Bading, H
影响因子：
4.8
作者：
Gao, L;Cueto, MA;Atadja, P
通讯作者：
Atadja, P