Distribution of short-wavelength-sensitive cones in human fetal and postnatal retina: early development of spatial order and density profiles
Distribution of short-wavelength-sensitive cones in human fetal and postnatal retina: early development of spatial order and density profiles
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DOI：
10.1016/j.visres.2004.03.030
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发表时间：
2004-08-01
期刊：
影响因子：
1.8
通讯作者：
Provis, JM
中科院分区：
文献类型：
--
作者：
Cornish, EE;Hendrickson, AE;Provis, JM
利用抗短波敏感视蛋白抗体分析了发育和成人视网膜中短波敏感光感受器（s -cone）的空间密度和分布。统计试验表明，在妊娠20周之前，s锥嵌合与随机分布没有明显区别，但到妊娠20周时，s锥嵌合与随机分布在凹周区域有显著不同，如先前报道的成人视网膜。发育过程中空间密度的变化与光感受器种群向初期中央凹的位移一致，因此在20 WG之前，s锥的峰值密度在距中央凹1.7 mm处，但在20 WG时已在距中央凹800 mm以内。(C) 2004 Elsevier Ltd.版权所有。
We analysed spatial density and distribution of short-wavelength-sensitive photoreceptors (S-cones) in developing and adult human retinae using antibody against short-wavelength-sensitive opsin. Statistical tests indicate that before 20 weeks of gestation (WG) the S-cone mosaic is not distinguishable from a random distribution, but by 20 WG is significantly different from a random distribution in the perifoveal region, as reported previously for adult retina. Changes in spatial density during development are consistent with displacement of the photoreceptor population towards the incipient fovea so that prior to 20 WG, peak S-cone density is >1.7 mm from the fovea, but is within 800 mum of the fovea by 20 WG. (C) 2004 Elsevier Ltd. All rights reserved.