Nanostructured lipid carriers: Promising drug delivery systems for future clinics
Nanostructured lipid carriers: Promising drug delivery systems for future clinics
复制标题
DOI：
10.1016/j.nano.2015.09.004
复制
发表时间：
2016-01-01
影响因子：
5.4
通讯作者：
Preat, Veronique
中科院分区：
文献类型：
--
作者：
Beloqui, Ana;Angeles Solinis, Maria;Preat, Veronique
在过去的十年中，描述纳米结构脂质载体(NLCS)配方的研究数量急剧增加。NLC开发的增加主要是由于脂基纳米粒配方工艺过程中的障碍被克服，以及对NLCS通过不同给药途径传输的潜在机制的了解增加。本文旨在通过新的NLC应用提供成功结果的例子，对NLC作为未来临床受控给药系统的技术现状进行综述。报道的数据清楚地说明了这些纳米颗粒在不久的将来用于新型治疗的前景。来自临床编辑：最近随着不断的研究，对基于纳米结构脂质载体(NLC)的配方的理解有所提高。其结果是，这些药物在临床环境中的使用有所增加。在这篇全面的综述中，作者讨论了纳米结构脂质载体作为受控给药系统的现状和主要挑战。(C)2015 Elsevier Inc.保留所有权利。
During the past decade, the number of studies describing nanostructured lipid carriers (NLCs)-based formulations has been dramatically increased. The raise in NLC exploitation is essentially due to defeated barriers within the technological process of lipid-based nanoparticles' formulation and increased knowledge of the underlying mechanisms of transport of NLCs via different routes of administration. This review article aims to give an overview on the current state of the art of NLC as controlled drug delivery systems for future clinics through novel NLC applications providing examples of successfull outcomes. The reported data clearly illustrate the promise of these nanoparticles for novel treatments in the near future.From the Clinical Editor: The understanding of the nanostructured lipid carriers (NLC)-based formulations has improved with continuing research recently. The result has seen an increase in the use of these in the clinical setting. In this comprehensive review, the authors discussed the current state and major challenges in the use of nanostructured lipid carriers as controlled drug delivery systems. (C) 2015 Elsevier Inc. All rights reserved.