Temporal cluster of herpes simplex encephalitis: investigation by restriction endonuclease cleavage of viral DNA.
Temporal cluster of herpes simplex encephalitis: investigation by restriction endonuclease cleavage of viral DNA.
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单纯疱疹脑炎颞丛：通过限制性核酸内切酶切割病毒 DNA 进行研究。
DOI：
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发表时间：
1980
影响因子：
6.4
通讯作者：
M. Hirsch
中科院分区：
文献类型：
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作者：
S. Hammer;T. Buchman;L. D'Angelo;A. Karchmer;B. Roizman;M. Hirsch
1977年夏天，在波士顿的马萨诸塞州总医院，在三个月的时间里，发现了8例经脑活检证实的单纯疱疹病毒性脑炎患者。这些病例不寻常的时间聚集性引起了正式的流行病学调查。没有发现这些患者之间存在显着联系，对限制性内切酶HsuI和HpaI产生的八种病毒分离株中的七种的切割产物的分析表明它们是不同的。因此，这个集群似乎是一个随机事件。然而，它的发生强调了疱疹性脑炎在这个国家并不罕见。此外，DNA的限制性内切酶切割的效用在澄清病毒性疾病的流行病学是强调。
Eight patients with brain biopsy-proven herpes simplex encephalitis were seen at the Massachusetts General Hospital, Boston, within a three-month period in the summer of 1977. The unusual temporal clustering of these cases engendered a formal epidemiologic investigation. No significant link among these patients was uncovered, and analysis of the cleavage products of seven of the eight viral isolates produced by the restriction endonucleases HsuI and HpaI showed that they were different. This cluster thus appears to have been a random event. Its occurrence, however, emphasizes that herpes encephalitis is not a rare disease in this country. In addition, the utility of restriction enzyme cleavage of DNA in clarifying the epidemiology of viral disease is underscored.