Diet and Pancreatic Cancer Prevention.
Diet and Pancreatic Cancer Prevention.
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DOI：
10.3390/cancers7040892
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发表时间：
2015-11-23
期刊：
影响因子：
5.2
通讯作者：
Falasca M
中科院分区：
文献类型：
--
作者：
Casari I;Falasca M
胰腺癌无疑是预后最差、生存率最低的恶性肿瘤。这种高度侵袭性的疾病很少在早期被诊断出来，并且由于其对放疗和化疗的抵抗而难以治疗。因此，迫切需要澄清胰腺癌的病因并确定预防策略以降低其在人群中的发病率。某些情况，如吸烟习惯、超重和糖尿病，已被确定为胰腺癌的潜在诱发因素，这表明饮食可能发挥作用。低脂肪和低糖饮食，加上健康的生活方式、定期锻炼、减轻体重和不吸烟，可能有助于预防胰腺癌和许多其他癌症类型。此外，越来越多的证据表明，某些食物可能具有化疗预防特性。事实上，大量摄入新鲜水果和蔬菜已被证明可以降低患胰腺癌的风险，最近的流行病学研究表明，食用坚果具有预防胰腺癌的作用。因此，饮食可能对胰腺癌的发展产生影响，需要进一步研究来评估特定食物对这种疾病的潜在化学预防作用。这篇综述总结了饮食习惯的作用及其对胰腺癌影响的关键证据，并重点关注饮食与胰腺癌风险之间关联的可能机制。
Pancreatic cancer is without any doubt the malignancy with the poorest prognosis and the lowest survival rate. This highly aggressive disease is rarely diagnosed at an early stage and difficult to treat due to its resistance to radiotherapy and chemotherapy. Therefore, there is an urgent need to clarify the causes responsible for pancreatic cancer and to identify preventive strategies to reduce its incidence in the population. Some circumstances, such as smoking habits, being overweight and diabetes, have been identified as potentially predisposing factors to pancreatic cancer, suggesting that diet might play a role. A diet low in fat and sugars, together with a healthy lifestyle, regular exercise, weight reduction and not smoking, may contribute to prevent pancreatic cancer and many other cancer types. In addition, increasing evidence suggests that some food may have chemo preventive properties. Indeed, a high dietary intake of fresh fruit and vegetables has been shown to reduce the risk of developing pancreatic cancer, and recent epidemiological studies have associated nut consumption with a protective effect against it. Therefore, diet could have an impact on the development of pancreatic cancer and further investigations are needed to assess the potential chemo preventive role of specific foods against this disease. This review summarizes the key evidence for the role of dietary habits and their effect on pancreatic cancer and focuses on possible mechanisms for the association between diet and risk of pancreatic cancer.