Immune Responses to Neisseria gonorrhoeae: Challenges and Opportunities With Respect to Pelvic Inflammatory Disease.
Immune Responses to Neisseria gonorrhoeae: Challenges and Opportunities With Respect to Pelvic Inflammatory Disease.
复制标题
对淋病奈瑟菌的免疫反应：盆腔炎症的挑战和机遇。
DOI：
10.1093/infdis/jiaa766
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Russell,MichaelW
中科院分区：
文献类型：
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作者：
Russell,MichaelW
在女性生殖道感染淋病奈瑟菌后，盆腔炎和不孕症经常发生，但从各种可能性中确定其病因存在困难。利用血清学来确定病原体是复杂的，有许多因素，目前还没有免疫学测试来明确地确定一个人目前是否感染或已经感染。淋病。N.广泛的抗原性变异性。淋病及其与人类常见携带的其他奈瑟氏菌共有的抗原的表达使对所有淋球菌菌株具有特异性的检测产生了问题。然而，被确定为潜在疫苗的新的保守淋球菌抗原可能会在诊断分析中得到更多的应用。淋病淋病也会干扰获得性免疫反应，而且对非复杂感染的抗体反应通常很弱。阐明了N。淋病对人体免疫系统的影响可能有助于人们更好地了解盆腔炎和不孕症的发病机制。
Pelvic inflammatory disease and infertility frequently develop after female genital tract infection withNeisseria gonorrhoeae, but determining their etiology from among various possibilities presents difficulties. Exploitation of serology to identify the causative agent is complicated by numerous factors, and no immunological test currently exists to determine unequivocally whether an individual currently is, or has been, infected withN. gonorrhoeae. The extensive antigenic variability ofN. gonorrhoeaeand its expression of antigens shared with otherNeisseriaspecies commonly carried in humans render problematic an assay that is specific for all gonococcal strains. However, novel conserved gonococcal antigens identified for potential vaccines may find additional application in diagnostic assays.N. gonorrhoeaealso interferes with the adaptive immune response, and antibody responses to uncomplicated infection are usually weak. Elucidating the mechanisms wherebyN. gonorrhoeaemanipulates the human immune system may lead to improved understanding of the pathogenesis of pelvic inflammatory disease and infertility.