Inverted-U-shaped correlation between dopamine receptor availability in striatum and sensation seeking
Inverted-U-shaped correlation between dopamine receptor availability in striatum and sensation seeking
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DOI：
10.1073/pnas.0912319107
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发表时间：
2010-02-23
影响因子：
11.1
通讯作者：
Moller, Arne
中科院分区：
文献类型：
--
作者：
Gjedde, Albert;Kumakura, Yoshitaka;Moller, Arne
感觉寻求是一种核心的人格特征，随着年龄的增长，男性和女性的感觉寻求能力都会下降，纹状体和皮质区域的多巴胺D-2/3受体的密度和可用性也会下降。相比之下，在一个特定的年龄寻求新奇与多巴胺受体的可用性成反比。对这些发现最简单的解释是，朱克曼量表上的感觉寻求等级与多巴胺D-2/3受体可用性之间存在倒U形相关性。为了验证感觉寻求型人格与多巴胺受体可用性之间存在倒U型关系的说法，我们使用PET记录了18名健康男性纹状体中的[C-11]雷氯必利结合。在这里，我们报告说，一个倒U形显着匹配的受体的可用性作为一个功能的祖克曼评分，最大的结合潜力观察到的范围的中间。倒U形与感觉寻求和多巴胺能神经传递对多巴胺的反应性（“增益”）之间的负相关性一致。相关性反映了Zuckerman分数与纹状体中的多巴胺受体密度线性相关，但与多巴胺浓度非线性相关。较高的多巴胺占有率和多巴胺浓度解释了驱使受折磨的个体寻求感觉的动机，这与对成瘾行为的保护减少是低结合电位个体的特征一致。
Sensation seeking is a core personality trait that declines with age in bothmenand women, as do also both density and availability of the dopamine D-2/3 receptors in striatum and cortical regions. In contrast, novelty seeking at a given age relates inversely to dopamine receptor availability. The simplest explanation of these findings is an inverted-U-shaped correlation between ratings of sensation seeking on the Zuckerman scale and dopamine D-2/3 receptor availability. To test the claim of an inverted-U-shaped relation between ratings of the sensation-seeking personality and measures of dopamine receptor availability, we used PET to record [C-11]raclopride binding in striatum of 18 healthy men. Here we report that an inverted-U shape significantly matched the receptor availability as a function of the Zuckerman score, with maximum binding potentials observed in the midrange of the scale. The inverted-U shape is consistent with a negative correlation between sensation seeking and the reactivity ("gain") of dopaminergic neurotransmission to dopamine. The correlation reflects Zuckerman scores that are linearly linked to dopamine receptor densities in the striatum but nonlinearly linked to dopamine concentrations. Higher dopamine occupancy and dopamine concentrations explain the motivation that drives afflicted individuals to seek sensations, in agreement with reduced protection against addictive behavior that is characteristic of individuals with low binding potentials.