Kinetics, salivary excretion of amphetamine isomers, and effect of urinary pH
Kinetics, salivary excretion of amphetamine isomers, and effect of urinary pH
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安非他明异构体的动力学、唾液排泄以及尿液 pH 值的影响
DOI：
10.1002/cpt1978235585
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发表时间：
1978
影响因子：
6.7
通讯作者：
D. Azarnoff
中科院分区：
文献类型：
--
作者：
S. H. Wan;S. Matin;D. Azarnoff
在尿液酸化和碱化的条件下，将安非他明作为外消旋混合物以及(+)-和(-)-异构体给予健康受试者。测量每种异构体的血浆和唾液浓度并确定各个异构体的动力学。 (+)-苯丙胺比(-)-异构体消除得更快。在碱性尿液 pH 条件下，异构体之间的半衰期差异最大。唾液安非他明水平高于血浆水平，并且在吸收后阶段与血浆药物水平成正比。
Amphetamine was administered to healthy subjects as the racemic mixture and as (+)‐and (−)‐isomers under conditions of urine acidification and alkalinization. Plasma and saliva concentration of each isomer was measured and the kinetics of the individual isomers were determined. (+)‐amphetamine was eliminated more rapidly than the (−)‐isomer. The difference in half‐life between isomers was maximal under basic urinary pH conditions. Saliva amphetamine levels were higher than plasma levels and in the postabsorptive phase were predictably proportional to plasma drug levels.