TDCS over PPC or DLPFC does not improve visual working memory capacity
TDCS over PPC or DLPFC does not improve visual working memory capacity
复制标题
DOI：
10.1038/s44271-024-00067-8
复制
发表时间：
2024-03
期刊：
影响因子：
--
通讯作者：
Shuangke Jiang;Myles Jones;C. C. von Bastian-C.
中科院分区：
文献类型：
--
作者：
Shuangke Jiang;Myles Jones;C. C. von Bastian-C.
非侵入性脑刺激被认为是一种可能的干预措施，可以带来认知益处，包括视觉工作记忆（VWM）。然而，研究结果不一致，可能是由于方法问题。 Wang 等人最近进行的一项备受瞩目的研究。据报道，在后顶叶皮层（PPC）上进行阳极经颅直流电刺激（tDCS），但在背外侧前额叶皮层（DLPFC）上没有，选择性地提高了 VWM 能力，但没有提高精度，特别是在高 VWM 负荷下。因此，在当前预先注册的概念复制研究中，我们考虑了原始研究中关键的潜在方法学问题，并测试了证明先前报告的效果所需的足够数量的参与者（n = 48 与 n = 20 相比）。参与者接受平衡 PPC、DLPFC 和假刺激，然后完成 360 次连续定向复制任务试验，任务刺激和设置略有变化。我们没有发现 PPC 刺激的选择性作用的证据。相反，我们的结果表明，无论刺激区域和 VWM 负载如何，tDCS 效应都不存在，这在很大程度上得到了大量至强贝叶斯证据的支持。因此，我们的结果挑战了之前报道的单次阳极 PPC-tDCS 对 VWM 的好处。
Non-invasive brain stimulation has been highlighted as a possible intervention to induce cognitive benefits, including on visual working memory (VWM). However, findings are inconsistent, possibly due to methodological issues. A recent high-profile study by Wang et al. reported that anodal transcranial direct current stimulation (tDCS) over posterior parietal cortex (PPC), but not over dorsolateral prefrontal cortex (DLPFC), selectively improved VWM capacity but not precision, especially at a high VWM load. Thus, in the current pre-registered conceptual replication study, we accounted for the key potential methodological issues in the original study and tested an adequate number of participants required to demonstrate the previously reported effects (n = 48 compared to n = 20). Participants underwent counterbalanced PPC, DLPFC and sham stimulation before completing 360 trials of a continuous orientation-reproduction task with a slight variation of task stimuli and setup. We found no evidence for the selective effect of PPC stimulation. Instead, our results showed that tDCS effects were absent regardless of stimulation region and VWM load, which was largely supported by substantial to strong Bayesian evidence. Therefore, our results challenge previously reported benefits of single-session anodal PPC-tDCS on VWM.