Association of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PPARGC1A) gene polymorphisms and type 2 diabetes mellitus: a meta-analysis
Association of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PPARGC1A) gene polymorphisms and type 2 diabetes mellitus: a meta-analysis
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过氧化物酶体增殖物激活受体 γ 共激活剂 1 α (PPARGC1A) 基因多态性与 2 型糖尿病的关联：荟萃分析
DOI：
10.1002/dmrr.1158
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发表时间：
2011-02-01
影响因子：
8
通讯作者：
Gu, Dongfeng
中科院分区：
文献类型：
--
作者：
Yang, Ying;Mo, Xingbo;Gu, Dongfeng
背景过氧化物酶体增殖物激活受体γ共激活因子1 α（PPARGC 1A）多态性与2型糖尿病（T2 DM）的相关性已在多项研究中进行了研究，但这些研究得出了相互矛盾的结果。本研究采用Meta分析方法，对PPARGC 1A基因Gly 482 Ser、Thr 394 Thr和Thr 612 Met多态性与2型糖尿病的相关性进行研究。采用加性模型分析3个多态性位点与2型糖尿病的关联性。如果研究之间存在异质性，则使用随机效应模型。结果共纳入23篇文献，其中Gly 482 Ser纳入7539例，对照9562例; Thr 394 Thr纳入1818例，对照2376例; Thr 612 Met纳入2042例，对照1289例。在所有合格研究的综合分析中，发现Gly 482 Ser、Thr 394 Thr与T2 DM之间存在显著相关性，合并比值比分别为1.19 [95%置信区间（CI）1.05-1.34]和1.33（95%CI 1.04-1.70），但研究间存在很大异质性。在亚组荟萃分析中，我们发现Gly 482 Ser和Thr 394 Thr多态性与2型糖尿病的风险相关，合并优势比为1.66（95% CI 1.28-2.15）和1.72（95% CI 1.45-2.03）;结论PPARGC 1A基因Gly 482 Ser和Thr 394 Thr多态性与2型糖尿病的发病风险显著相关，尤其是印度人。Thr 612 Met与T2 DM的发病风险无相关性。版权所有（C）2011约翰威利父子有限公司
Background The association between peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PPARGC1A) polymorphisms and type 2 diabetes mellitus (T2DM) has been investigated in several studies, but these studies yielded contradictory results. We conducted a meta-analysis to assess the association between three polymorphisms (Gly482Ser, Thr394Thr and Thr612Met) in PPARGC1A and T2DM.Methods A literature-based search was conducted to collect data. The additive model was chosen to investigate the association between the three polymorphisms and T2DM. The random effects model was used if there was heterogeneity between studies. In addition, subgroup meta-analyses were made according to the ethnic groups.Results Twenty-three studies were enrolled in this meta-analysis (7539 cases and 9562 controls for Gly482Ser, 1818 cases and 2376 controls for Thr394Thr, 2042 cases and 1289 controls for Thr612Met). In the combined analysis of all eligible studies, a significant association was found between Gly482Ser, Thr394Thr and T2DM with pooled odds ratios 1.19 [95% confidence interval (CI) 1.05-1.34] and 1.33 (95% CI 1.04-1.70), respectively, but great heterogeneity was found between studies. In the subgroup meta-analyses, we found that Gly482Ser and Thr394Thr polymorphisms were associated with the risk of T2DM, and the pooled odds ratios were 1.66 (95% CI 1.28-2.15) and 1.72 (95% CI 1.45-2.03), respectively, in the Indian population; no significant evidence was found in the Caucasian and East Asian populations.Conclusions This meta-analysis indicated that Gly482Ser and Thr394Thr polymorphisms of PPARGC1A gene were significantly associated with the risk of T2DM, especially in the Indian population. No relationship was found between the Thr612Met and risk of T2DM. Copyright (C) 2011 John Wiley & Sons, Ltd.