Regulation of hematopoiesis by T lymphocytes and natural killer cells.
Regulation of hematopoiesis by T lymphocytes and natural killer cells.
复制标题
T 淋巴细胞和自然杀伤细胞对造血的调节。
DOI：
10.1016/s1040-8428(87)80009-4
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Perussia,B
中科院分区：
文献类型：
--
作者：
Trinchieri,G;Murphy,M;Perussia,B
T淋巴细胞和自然杀伤（NK）细胞发挥调节造血细胞的生长和分化的刺激和抑制作用。活化的T和NK细胞已被证明在骨髓衰竭的不同病理状态中，并被认为在疾病的发病机制中发挥作用。T细胞和NK细胞也被证明是同种异体和同基因供体/受体组合中骨髓移植排斥反应的原因。淋巴细胞可以通过直接细胞接触或通过释放可溶性因子来调节造血细胞的生长，所述可溶性因子例如集落刺激因子、免疫干扰素、趋化因子和肿瘤坏死因子，其对造血前体细胞具有活性。
T lymphocytes and natural killer (NK) cells exert both stimulatory and suppressive effects that regulate growth and differentiation of hematopoietic cells. Activated T and NK cells have been demonstrated in different pathological states of bone marrow failure and are proposed to play a role in the pathogenesis of the disease. T and NK cells have also been shown to be responsible for bone marrow graft rejection in both allogeneic and syngeneic donor/recipient combinations. Lymphocytes can regulate hematopoietic cell growth by direct cellular contact or by releasing soluble factors, such as colony-stimulating factors, immune interferon, lymphotoxin, and tumor necrosis factor, active on hematopoietic precursor cells.