Synthesis of β‐Lapachone, a Potential Anticancer Agent from the Lapacho Tree
Synthesis of β‐Lapachone, a Potential Anticancer Agent from the Lapacho Tree
复制标题
DOI：
10.1002/ejoc.201403064
复制
发表时间：
2014-11
影响因子：
2.8
通讯作者：
T. Katoh;Hiromitsu Monma;Junjiro Wakasugi;Koichi Narita;T. Katoh
中科院分区：
文献类型：
--
作者：
T. Katoh;Hiromitsu Monma;Junjiro Wakasugi;Koichi Narita;T. Katoh
以市售 1,4-萘醌为原料，通过四个步骤有效合成了一种药学上重要的天然产物 β-拉帕酮，总产率为 70%。合成的关键步骤是通过有利的环化/水合/氧化级联过程将2-异戊二烯基-1,4-萘醌直接转化为β-拉帕酮。
A pharmaceutically important natural product, β-lapachone, was efficiently synthesized in four steps in 70 % overall yield starting from commercially available 1,4-naphthoquinone. The key step of the synthesis was the direct conversion of 2-prenyl-1,4-naphthoquinone into β-lapachone through an advantageous cyclization/hydration/oxidation cascade process.