Polymorphism of the human immunodeficiency virus type 2 (HIV-2) protease gene and selection of drug resistance mutations in HIV-2-infected patients treated with protease inhibitors
Polymorphism of the human immunodeficiency virus type 2 (HIV-2) protease gene and selection of drug resistance mutations in HIV-2-infected patients treated with protease inhibitors
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DOI：
10.1128/jcm.43.1.484-487.2005
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发表时间：
2005-01-01
影响因子：
9.4
通讯作者：
Descamps, D
中科院分区：
文献类型：
--
作者：
Damond, F;Brun-Vezinet, F;Descamps, D
我们描述了94例初治患者的人类免疫缺陷病毒2型（HIV-2）蛋白酶基因的基线多态性和17例蛋白酶抑制剂治疗患者的纵向随访。与HIV-2共有序列相比，基线多态性涉及47个位点。在对应于HIV-1耐药突变的位置以及目前对HIV-1的影响未知的位置观察到治疗下选择的取代。
We described the baseline polymorphism of the human immunodeficiency virus type 2 (HIV-2) protease gene from 94 treatment-naive patients and the longitudinal follow-up of 17 protease inhibitor-treated patients. Compared to the HIV-2 consensus sequences, baseline polymorphism involved 47 positions. Substitutions selected under treatment were observed at positions corresponding to HIV-1 resistance mutations as well as at positions of currently unknown impact on HIV-1.