THE QUANTITATIVE-ANALYSIS OF MAMMOGRAPHIC DENSITIES
THE QUANTITATIVE-ANALYSIS OF MAMMOGRAPHIC DENSITIES
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DOI：
10.1088/0031-9155/39/10/008
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发表时间：
1994-10-01
影响因子：
3.5
通讯作者：
YAFFE, MJ
中科院分区：
文献类型：
--
作者：
BYNG, JW;BOYD, NF;YAFFE, MJ
基于放射学评估的乳房X线摄影实质定量分类已被证明是发展乳腺癌风险的最强估计之一。然而，现有的分类方案受到粗分类尺度的限制。此外，主观性可能导致观察者之间和观察者内部的巨大差异。在这里，我们提出了一个交互式阈值技术应用于数字化的电影屏幕乳房X线摄影，评估的比例乳房X线摄影图像表示放射致密组织。观察者在汽车显示器上观看图像，并选择灰度阈值，从中识别乳房和乳房中的致密组织区域。然后根据图像直方图计算放射线密度的比例。对30名妇女的乳房X线片进行了评价，并与放射科医师对X线片密度的6类主观分类有很好的相关性（R > 0.91，斯皮尔曼系数）。发现该技术非常可靠，观察者之间的组内相关系数通常R > 0.9。该技术可能在常规乳房X线摄影分析中发挥作用，以评估风险类别，并作为乳腺癌病因学研究的工具，特别是在潜在的预防性干预期间监测乳腺实质的变化。
Quantitative classification of mammographic parenchyma based on radiological assessment has been shown to provide one of the strongest estimates of the risk of developing breast cancer. Existing classification schemes, however, are limited by coarse category scales. In addition, subjectivity can lead to sizeable interobserver and intraobserver variations. Here, we propose an interactive thresholding technique applied to digitized film-screen mammograms, which assesses the proportion of the mammographic image representing radiographically dense tissue. Observers viewed images on a car display and selected grey-level thresholds from which the breast and regions of dense tissue in the breast were identified. The proportion of radiographic density was then calculated from the image histogram. The technique was evaluated for the mammograms of 30 women and is well correlated (R > 0.91, Spearman coefficient) with a six-category subjective classification of radiographic density by radiologists. The technique was found to be very reliable with an intraclass correlation coefficient between observers typically R > 0.9. This technique may have a role in routine mammographic analysis for the purpose of assessing risk categories and as a tool in studies of the etiology of breast cancer, in particular for monitoring changes in breast parenchyma during potential preventive interventions.