Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
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DOI：
10.1016/j.ccr.2012.02.022
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发表时间：
2012-03-20
期刊：
影响因子：
50.3
通讯作者：
Coussens, Lisa M.
中科院分区：
文献类型：
--
作者：
Hanahan, Douglas;Coussens, Lisa M.
突变破坏的癌（干）细胞是肿瘤发展和进展的驱动力。然而，这些转化的细胞不能单独完成。表面上正常的组织和骨髓来源的（基质）细胞的集合体被募集以构成致瘤微环境。癌症的大多数特征通过基质细胞类型和独特的亚细胞类型的库的贡献而在不同程度上得以实现和维持。它们对标志性能力的贡献功能越来越被人们所理解，与肿瘤癌细胞的相互通信也是如此，肿瘤癌细胞介导了它们的招募、激活、编程和持久性。这种增强的理解为抗癌治疗提供了有趣的新靶点。
Mutationally corrupted cancer (stem) cells are the driving force of tumor development and progression. Yet, these transformed cells cannot do it alone. Assemblages of ostensibly normal tissue and bone marrow-derived (stromal) cells are recruited to constitute tumorigenic microenvironments. Most of the hallmarks of cancer are enabled and sustained to varying degrees through contributions from repertoires of stromal cell types and distinctive subcell types. Their contributory functions to hallmark capabilities are increasingly well understood, as are the reciprocal communications with neoplastic cancer cells that mediate their recruitment, activation, programming, and persistence. This enhanced understanding presents interesting new targets for anticancer therapy.