Mussel-Inspired pH-Switched Assembly of Capsules with an Ultrathin and Robust Nanoshell
Mussel-Inspired pH-Switched Assembly of Capsules with an Ultrathin and Robust Nanoshell
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受贻贝启发，采用超薄且坚固的纳米壳进行 pH 切换胶囊组装
DOI：
10.1021/acsami.9b11445
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发表时间：
2019-08-07
影响因子：
9.5
通讯作者：
Jiang, Zhongyi
中科院分区：
文献类型：
--
作者：
Cai, Ziyi;Shi, Jiafu;Jiang, Zhongyi
具有纳米和坚固的纳米壳的封闭膜，也称为胶囊，已经引起了人们对在许多应用中使用的极大兴趣，迫切需要简便的制备方法。受贻贝分泌的足蛋白的pH程序化粘附/内聚的启发，通过在牺牲碳酸钙（CaCO 3）模板上的pH切换组装来制造具有稳定和坚固的纳米壳的多酚/聚胺胶囊。多酚坚持在pH 6.0的模板，并迅速凝聚与多胺在pH 8.0。pH切换组装过程仅在几分钟内完成，其中多酚和多胺之间发生静电相互作用和化学缀合的多个实例。结果，该胶囊表现出类似于10 nm的纳米壳厚度和类似于1.575 GPa的上级机械强度（弹性模量）。通过在管腔中包裹酶来制备细胞模拟物，并且在重复使用期间呈现出接近70%沿着的活性恢复，几乎没有活性下降。然后在胶囊的纳米壳上施加胺或酚基团以诱导二氧化钛或银纳米颗粒的产生，这可以将胶囊的应用扩展到光和生物相关领域。我们的研究不仅加深了对贻贝粘附过程的理解，而且为不同应用的功能材料提供了一种通用方法。
Enclosed films, also called capsules, bearing an ultrathin and robust nanoshell have sparked much interest for use in many applications, for which facile preparation methods are urgently pursued. Inspired by the pH-programmed adhesion/cohesion of mussel-secreted foot proteins, polyphenol/polyamine capsules with an ultrathin and robust nanoshell are fabricated through a pH-switched assembly on sacrificial calcium carbonate (CaCO3) templates. Polyphenols adhere to the templates at pH 6.0 and rapidly cohere with polyamines at pH 8.0. The pH-switched assembly process is accomplished in only a few minutes where multiple instances of electrostatic interactions and chemical conjugation between polyphenols and polyamines occur. As a result, the capsules exhibit a nanoshell thickness of similar to 10 nm and a superior mechanical strength of similar to 1.575 GPa (elasticity modulus). Cell mimics are prepared through encasing enzymes in the lumen and present an activity recovery of similar to 70% along with little activity decline during reuse. Amine or phenolic groups on the nanoshell of capsules are then applied to induce the generation of titania or silver nanoparticles, which may expand the applications of the capsules to the photo- and biorelated realms. Our study not only deepens the understanding of the adhering process of mussels but also offers a generic method toward functional materials for diverse applications.