Short-term metreleptin treatment of patients with anorexia nervosa: rapid on-set of beneficial cognitive, emotional, and behavioral effects
Short-term metreleptin treatment of patients with anorexia nervosa: rapid on-set of beneficial cognitive, emotional, and behavioral effects
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DOI：
10.1038/s41398-020-00977-1
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发表时间：
2020-08-27
影响因子：
6.8
通讯作者：
Hebebrand, Johannes
中科院分区：
文献类型：
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作者：
Milos, Gabriella;Antel, Jochen;Hebebrand, Johannes
为了检验神经性厌食症患者低循环瘦素水平正常化可改善多动的假设，三名患有多动的重病女性接受了metreleptin（重组人瘦素）标签外治疗长达14天。两名患者的活动驱动力、对食物的重复想法、内心不安和体重恐惧症减少。令人惊讶的是，所有患者的抑郁症都迅速改善。未发生严重不良事件。由于非对照病例系列的明显局限性，必须进行安慰剂对照临床试验来证实观察到的有益效果的快速起效。我们的研究结果表明，在神经性厌食症的精神和行为表型的低肽血症的重要作用。
To examine the hypothesis that normalization of low circulating leptin levels in patients with anorexia nervosa ameliorates hyperactivity, three seriously ill females with hyperactivity were treated off-label with metreleptin (recombinant human leptin) for up to 14 days. Drive for activity, repetitive thoughts of food, inner restlessness, and weight phobia decreased in two patients. Surprisingly, depression improved rapidly in all patients. No serious adverse events occurred. Due to obvious limitations of uncontrolled case series, placebo-controlled clinical trials are mandatory to confirm the observed rapid onset of beneficial effects. Our findings suggest an important role of hypoleptinemia in the mental and behavioral phenotype of anorexia nervosa.