Acid and pepsin secretion in duodenal ulcer patients in response to graded doses of pentagastrin or pentagastrin and carbacholine before and after proximal gastric vagotomy.
Acid and pepsin secretion in duodenal ulcer patients in response to graded doses of pentagastrin or pentagastrin and carbacholine before and after proximal gastric vagotomy.
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十二指肠溃疡患者在近端胃迷走神经切断术前后对分级剂量的五肽胃泌素或五肽胃泌素和卡巴胆碱的反应，胃酸和胃蛋白酶的分泌。
DOI：
10.1080/00365521.1974.12096867
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发表时间：
1974
影响因子：
1.9
通讯作者：
I. Liavåg
中科院分区：
文献类型：
--
作者：
M. Roland;A. Berstad;I. Liavåg
Roland，M.，Berstad，A. 和 Liavåg，I。近端胃迷走神经切断术前后分级剂量的五肽胃泌素或五肽胃泌素和卡巴胆碱对十二指肠溃疡患者的酸和胃蛋白酶分泌的影响。扫描。 J. Gastroent.1974,9, 511–518. 在 9 名十二指肠溃疡患者中，按随机顺序在不同日期静脉注射分级剂量的五肽胃泌素（0.15、1.5 或 15 µg/kg/hr）。这些测试在近端胃迷走神经切断术 (PGV) 之前、3 个月和 6 个月后进行。 6 个月时，将 1 或 2μg/kg/小时的卡巴胆碱与五肽胃泌素同时输注。 PGV 后，胃酸和胃蛋白酶的最大分泌能力分别降低 50% 和 42%。壁细胞和主细胞对五肽胃泌素刺激的敏感性降低。卡巴胆碱使壁细胞对五肽胃泌素的敏感性恢复至术前水平，但不影响平均最大酸分泌能力。卡巴胆碱影响术后胃蛋白酶的平均最大输出量，但不改变主细胞对五肽胃泌素的敏感性。然而，在 9 名患者中有 2 名患者中，卡巴胆碱几乎恢复了五肽胃泌素刺激的胃酸和胃蛋白酶分泌的迷走神经切断术前水平。
Roland, M., Berstad, A. & Liavåg, I. Acid and pepsin secretion in duodenal ulcer patients in response to graded doses of pentagastrin or pentagastrin and carbacholine before and after proximal gastric vagotomy.Scand. J. Gastroent.1974,9, 511–518.In 9 patients with duodenal ulcer graded doses of pentagastrin (0.15, 1.5, or 15µg/kg/hr) were infused intravenously on separate days in random order. The tests were performed before, 3 and 6 months after proximal gastric vagotomy (PGV). At 6 months one or twoµg/kg/hr of carbacholine was infused simultaneously with pentagastrin. After PGV maximal secretory capacity of acid and pepsin was reduced by 50 % and 42 % respectively. The sensitivity of the parietal and chief cells to pentagastrin stimulation decreased. Carbacholine restored the sensitivity of the parietal cells to pentagastrin to preoperative level but did not influence the mean maximal secretory capacity of acid. Carbacholine influenced the postoperative mean maximal output of pepsin without changing the sensitivity of the chief cells to pentagastrin. In 2 out of 9 patients, howewer, carbacholine nearly restored the prevagotomy level of pentagastrin-stimulated acid and pepsin secretion.