BIPOLAR-I - A 5-YEAR PROSPECTIVE FOLLOW-UP
BIPOLAR-I - A 5-YEAR PROSPECTIVE FOLLOW-UP
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DOI：
10.1097/00005053-199304000-00005
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发表时间：
1993-04-01
影响因子：
1.9
通讯作者：
MUELLER, TI
中科院分区：
文献类型：
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作者：
KELLER, MB;LAVORI, PW;MUELLER, TI
我们对172名先证者进行了长达5年的前瞻性随访，探讨了双相I型疾病的病程。根据先证者的症状是仅抑郁、仅躁狂还是混合/骑自行车，先证者被分成三类。可以获得从首发发作恢复、随后复发以及从第一次预期发作恢复的速率的数据。单纯躁狂先证者的恢复率(中位数，6周)明显快于混合/周期先证者(中位数，17周)，而单纯抑郁症先证者的恢复率(中位数，11周)。经过5年的随访，混合/循环患者从指标发作中恢复的累积概率仍然是最低的。与单纯躁狂症患者相比，混合/骑自行车先证者在从指标发作中恢复后复发的时间也要快得多。对于那些复发的患者，混合/循环患者从第一次前瞻性观察到的发作中恢复的累积概率最低。描述了这些患者所接受的治疗，并讨论了这种治疗可能如何影响病程和结果的结果。
We explored the course of bipolar I illness in 172 probands who were followed up prospectively for up to 5 years. Probands were grouped into three categories based on whether the symptoms of the index episode were only depressed, only manic, or mixed/cycling. Data were available for recovery from the index episode, subsequent relapse, and rates of recovery from the first prospective episode. Pure manic probands had a significantly faster rate of recovery (median, 6 weeks) than the mixed/cycling probands (median, 17 weeks), and the pure depressive probands had an intermediate rate (median, 11 weeks). After 5 years of follow-up the mixed/cycling patients continue to have the lowest cumulative probability of recovery from the index episode. Mixed/cycling probands also had a substantially faster time to relapse after recovery from the index episode compared with pure manic patients. For those patients who relapsed, the mixed/cycling patients had the lowest cumulative probability of recovery from the first prospectively observed episode. The treatment received by these patients is described and there is a discussion of how this treatment may have influenced the findings on course and outcome.