Topical Nano and Microemulsions for Skin Delivery.
Topical Nano and Microemulsions for Skin Delivery.
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DOI：
10.3390/pharmaceutics9040037
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发表时间：
2017-09-21
期刊：
影响因子：
5.4
通讯作者：
Roberts MS
中科院分区：
文献类型：
--
作者：
Nastiti CMRR;Ponto T;Abd E;Grice JE;Benson HAE;Roberts MS
纳米系统如微乳液（ME）和纳米乳液（NE）为靶向药物递送至皮肤和经由皮肤提供了相当多的机会。ME和NE是由油和水组成的稳定胶体系统，通过表面活性剂和助表面活性剂的混合物稳定，其作为局部皮肤递送系统受到特别关注。有相当大的范围来操纵制剂组分和特性，以实现最佳的生物利用度和最小的皮肤刺激。这包括掺入已建立的化学渗透增强剂以覆盖角质层脂质双层，从而降低初级皮肤屏障并增加渗透。这篇综述讨论了在皮肤给药的实用纳米系统，并侧重于局部和经皮给药的ME和NE的组成和表征。综述了皮肤给药的机制，包括通过角质层和毛囊，特别关注制剂的影响。
Nanosystems such as microemulsions (ME) and nanoemulsions (NE) offer considerable opportunities for targeted drug delivery to and via the skin. ME and NE are stable colloidal systems composed of oil and water, stabilised by a mixture of surfactants and cosurfactants, that have received particular interest as topical skin delivery systems. There is considerable scope to manipulate the formulation components and characteristics to achieve optimal bioavailability and minimal skin irritancy. This includes the incorporation of established chemical penetration enhancers to fluidize the stratum corneum lipid bilayers, thus reducing the primary skin barrier and increasing permeation. This review discusses nanosystems with utility in skin delivery and focuses on the composition and characterization of ME and NE for topical and transdermal delivery. The mechanism of skin delivery across the stratum corneum and via hair follicles is reviewed with particular focus on the influence of formulation.
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影响因子：
6
作者：
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通讯作者：
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DOI：
10.1016/s0927-7757(01)00543-x
发表时间：
2001-07-15
影响因子：
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作者：
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