Investigating the psychopharmacology of cognitive affective bias in rats using an affective tone discrimination task
Investigating the psychopharmacology of cognitive affective bias in rats using an affective tone discrimination task
复制标题
DOI：
10.1007/s00213-012-2932-5
复制
发表时间：
2013-04-01
影响因子：
3.4
通讯作者：
Robinson, Emma S. J.
中科院分区：
文献类型：
--
作者：
Anderson, Michael H.;Munafo, Marcus R.;Robinson, Emma S. J.
众所周知，情感状态会影响人类的行为，导致认知情感偏差，这可能在情绪障碍的发展和治疗中发挥重要作用。最近在包括老鼠在内的动物身上也显示出类似的偏向，这为在非人类物种中研究这些过程提供了一个机会。这项研究试图调查使用抗焦虑药物(安定)和抗抑郁药物(瑞波西汀或氟西汀)全身治疗的大鼠认知情感偏向的精神药理学。蒙面大鼠被训练来辨别两种不同的音调，并在适当的杠杆上做出反应，以获得奖励(食物)或避免惩罚(轻微的足部电击)。对急性或慢性药物治疗后的认知情感偏差进行了测试，包括参照音和中间歧义音。大鼠在交通工具条件下表现出负面判断偏差，而任何急性药物治疗，安定(0.3，1.0 mg/kg)，瑞波西汀(0.3-3.0 mg/kg)或氟西汀0.1-1.0 mg/kg都不能显著减弱这种偏差。急性瑞波西汀可显著降低对奖赏的预期，且呈剂量依赖关系。氟西汀的慢性治疗倾向于减少治疗1周后观察到的负面偏向，尽管没有观察到显著的治疗主要效果。这些初步的精神药理学研究结果表明，药物治疗可以不同地影响对与奖励和惩罚相关的线索做出反应的动机。我们的数据还表明，用这种方法量化的认知情感偏差可能对慢性抗抑郁药物治疗敏感，但对急性抗抑郁药物治疗不敏感。
Affective states are known to influence behaviour in humans resulting in cognitive affective biases, which may play an important role in the development and treatment of mood disorders. Similar biases have recently been shown in animals, including the rat, providing an opportunity to investigate these processes in non-human species.This study sought to investigate the psychopharmacology of cognitive affective bias in rats using systemic treatments with anxiolytic (diazepam) and antidepressant drugs (reboxetine or fluoxetine).Lister hooded rats were trained to discriminate two distinct tones and respond on the appropriate lever to either obtain reward (food) or avoid punishment (mild foot shock). Cognitive affective bias, following acute or chronic drug treatment, was investigated using test sessions where both reference tones and intermediate ambiguous tones were included.Rats exhibited a negative judgement bias under vehicle conditions which was not significantly attenuated by any of the acute drug treatments, diazepam (0.3, 1.0 mg/kg), reboxetine (0.3-3.0 mg/kg) or fluoxetine 0.1-1.0 mg/kg). Acute reboxetine induced a significant and dose-dependent decrease in the anticipation of reward. Chronic treatment with fluoxetine tended to reduce the negative bias observed in the rats after 1 week of treatment although no significant main effect of treatment was observed.The results from these initial psychopharmacological studies show that drug treatments can differentially affect motivation to respond to cues associated with reward versus punishment. Our data also suggest that cognitive affective bias, quantified using this method, may be sensitive to chronic but not acute antidepressant treatment.