Association between TNFSF4 tagSNPs and myocardial infarction in a Chinese Han population
Association between TNFSF4 tagSNPs and myocardial infarction in a Chinese Han population
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DOI：
10.4238/2015.june.8.11
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发表时间：
2015-01-01
影响因子：
0.4
通讯作者：
Xiong, X. -D.
中科院分区：
文献类型：
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作者：
Cheng, J.;Cen, J. -M.;Xiong, X. -D.
肿瘤坏死因子超家族成员4 （Tumor necrosis factor superfamily member 4, TNFSF4）在动脉粥样硬化的发生发展中起重要作用。然而，TNFSF4变异在心肌梗死（MI）发病机制中的生物学意义仍然知之甚少。我们研究了5个TNFSF4标记单核苷酸多态性（rs3861950、rs17346501、rs7518045、rs1234313和rs3850641）对285名中国心肌梗死患者和645名对照者个体心肌梗死易感性的影响。采用聚合酶链反应-连接酶检测反应法进行基因分型。在多因素logistic回归分析中，只有标记单核苷酸多态性rs7518045的TNFSF4对心肌梗死风险有显著影响；A等位基因（优势比= 0.68,95%可信区间= 0.46 ~ 1.00,P = 0.048）和AA基因型（优势比= 0.64,95%可信区间= 0.42 ~ 0.97,P = 0.036）与G等位基因和AG/GG联合基因型相比，分别与心肌梗死风险降低相关。此外，含有rs7518045A等位基因的rs3861950C-rs17346501C-rs7518045A-rs1234313G单倍型也显示出与心肌梗死风险降低的显著关联（优势比= 0.42,95%置信区间= 0.21-0.84,P = 0.011）。我们的研究表明，TNFSF4基因中rs7518045等位基因A和单倍型rs3861950C-rs17346501C-rs7518045A-rs1234313G与中国汉族人群心肌梗死风险降低相关。进一步的研究需要使用更大的样本量和不同的种族人群来证实我们的发现的总体有效性。
Tumor necrosis factor superfamily member 4 (TNFSF4) plays an important role in atherosclerosis development. However, the biological significance of TNFSF4 variants on myocardial infarction (MI) pathogenesis remains poorly understood. We investigated the influence of 5 TNFSF4 tagging single nucleotide polymorphisms (rs3861950, rs17346501, rs7518045, rs1234313, and rs3850641) on individual susceptibility to MI in a Chinese population of 285 MI patients and 645 controls. Genotyping was performed using the polymerase chain reaction-ligase detection reaction method. In multivariate logistic regression analysis, only the TNFSF4 tagging single nucleotide polymorphism rs7518045 exhibited a significant effect on MI risk; A allele (odds ratio = 0.68, 95% confidence interval = 0.46-1.00, P = 0.048) and AA genotype (odds ratio = 0.64, 95% confidence interval = 0.42-0.97, P = 0.036) were associated with a decreased risk of MI compared with the G allele and the combined AG/GG genotype, respectively. Moreover, the haplotype rs3861950C-rs17346501C-rs7518045A-rs1234313G containing the rs7518045 A allele also exhibited a significant association with a decreased risk for MI (odds ratio = 0.42, 95% confidence interval = 0.21-0.84, P = 0.011). Our study showed that the A allele of the rs7518045 and haplotype rs3861950C-rs17346501C-rs7518045A-rs1234313G in the TNFSF4 gene were associated with decreased MI risk in a Chinese Han population. Further studies using larger sample sizes and in diverse ethnic populations are needed to confirm the general validity of our findings.