An Electrochemical Approach to Directed Fluorination
An Electrochemical Approach to Directed Fluorination
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定向氟化的电化学方法
DOI：
10.1021/acs.joc.2c01886
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Lectka, Thomas
中科院分区：
文献类型：
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作者：
Holt, Eric;Wang, Muyuan;Harry, Stefan Andrew;He, Chengkun;Wang, Yuang;Henriquez, Nicolas;Xiang, Michael Richard;Zhu, Andrea;Ghorbani, Fereshte;Lectka, Thomas
电合成在有机化学领域，特别是在自由基介导的反应领域取得了复兴。在这里，我们报告了一种简单的定向电化学C-H氟化方法。使用dabconine介体、商业上可用的SelectFluor和RVC电极，我们提供了一系列基于类固醇的底物，具有合格的区域选择性导向基团，包括烯酮、酮和羟基，以及在内酰胺、亚胺、内酯和酯之前从未报道过的。
Electrosynthesis has made a revival in the field of organic chemistry and, in particular, radical-mediated reactions. Herein, we report a simple directed, electrochemical C–H fluorination method. Employing a dabconium mediator, commercially available Selectfluor, and RVC electrodes, we provide a range of steroid-based substrates with competent regioselective directing groups, including enones, ketones, and hydroxy groups, as well as never reported before lactams, imides, lactones, and esters.