Interval Between Infections and Viral Hierarchy Are Determinants of Viral Interference Following Influenza Virus Infection in a Ferret Model.
Interval Between Infections and Viral Hierarchy Are Determinants of Viral Interference Following Influenza Virus Infection in a Ferret Model.
复制标题
DOI：
10.1093/infdis/jiv260
复制
发表时间：
2015-12-01
期刊：
影响因子：
--
通讯作者：
Barr IG
中科院分区：
文献类型：
--
作者：
Laurie KL;Guarnaccia TA;Carolan LA;Yan AW;Aban M;Petrie S;Cao P;Heffernan JM;McVernon J;Mosse J;Kelso A;McCaw JM;Barr IG
背景：流行病学研究表明，在感染流感病毒后，宿主对其他流感病毒感染的易感性会降低一段短时间。 这种病毒干扰似乎与病毒之间的任何抗原相似性无关。我们使用人流感的雪貂模型来系统地研究病毒干扰。 方法：首先感染雪貂，然后在1-14天后用2009年和2010年流行的甲型H1N1流感pdm 09、甲型H3 N2流感和B流感病毒对进行攻击。 结果：当初次感染和随后的攻击之间的间隔<1周时，观察到病毒干扰。 这种效应是病毒特异性的，发生在抗原相关和不相关的病毒之间。当感染间隔1或3天时发生合并感染。初次病毒感染的持续脱落与二次攻毒后的病毒干扰相关。 结论：感染之间的间隔和病毒的顺序组合是病毒干扰的重要决定因素。 本研究中的流感病毒似乎根据其阻断或延迟感染的能力具有有序的层次结构，这可能有助于在流感季节经常看到的不同病毒的优势。
Background. Epidemiological studies suggest that, following infection with influenza virus, there is a short period during which a host experiences a lower susceptibility to infection with other influenza viruses. This viral interference appears to be independent of any antigenic similarities between the viruses. We used the ferret model of human influenza to systematically investigate viral interference. Methods. Ferrets were first infected then challenged 1–14 days later with pairs of influenza A(H1N1)pdm09, influenza A(H3N2), and influenza B viruses circulating in 2009 and 2010. Results. Viral interference was observed when the interval between initiation of primary infection and subsequent challenge was <1 week. This effect was virus specific and occurred between antigenically related and unrelated viruses. Coinfections occurred when 1 or 3 days separated infections. Ongoing shedding from the primary virus infection was associated with viral interference after the secondary challenge. Conclusions. The interval between infections and the sequential combination of viruses were important determinants of viral interference. The influenza viruses in this study appear to have an ordered hierarchy according to their ability to block or delay infection, which may contribute to the dominance of different viruses often seen in an influenza season.