Protected environment-prophylactic antibiotic program in the chemotherapy of acute leukemia
Protected environment-prophylactic antibiotic program in the chemotherapy of acute leukemia
复制标题
急性白血病化疗中的保护环境预防性抗生素方案
DOI：
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发表时间：
1971
影响因子：
3.1
通讯作者：
E. Frei
中科院分区：
文献类型：
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作者：
G. Bodey;E. Gehan;E. Freireich;E. Frei
33例急性白血病患者在保护环境（PE）单位接受化疗并接受预防性抗生素治疗。将这些患者的化疗效果与两组选定的对照患者进行比较。在PE单位治疗的患者的缓解期和生存期明显长于对照组患者。完全缓解的中位持续时间分别为55周和26周。PE组患者接受了更强化的化疗，出现了更严重和更长时间的中性粒细胞减少。当与循环中性粒细胞水平相关时，PE组患者的感染频率显著降低。在PE单元治疗的患者的完全缓解率略高于对照组（61% vs 55% vs 42%），并且更多的PE患者存活时间足够长，可以接受足够的化疗试验，但这些差异没有统计学意义
Thirty-three patients with acute leukemia underwent chemotherapy while in protected environment (PE) units and receiving prophylactic antibiotic regimens. The effects of chemotherapy in these patients were compared to two groups of selected control patients. The duration of remission and survival was significantly longer for patients treated in PE units than for the combined groups of control patients. The median duration of complete remission was 55 weeks and 26 weeks, respectively. The patients in the PE group received more Intensive chemotherapy and had more severe and prolonged neutropenia. The frequency of infection was significantly less among patients in the PE group when related to the level of circulating neutrophils. The complete remission rate was slightly higher for patients treated in the PE units than for either control group (61 vs 55 vs 42 per cent), and more of the PE patients survived long enough to receive an adequate trial of chemotherapy, but these differences were not statistically significant