Cigarettes, coffee, and preterm premature rupture of the membranes.
Cigarettes, coffee, and preterm premature rupture of the membranes.
复制标题
香烟、咖啡和早产胎膜早破。
DOI：
10.1093/oxfordjournals.aje.a116385
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发表时间：
1992
影响因子：
5
通讯作者：
Monson,RR
中科院分区：
文献类型：
--
作者：
Williams,MA;Mittendorf,R;Stubblefield,PG;Lieberman,E;Schoenbaum,SC;Monson,RR
胎膜早破（在妊娠37周之前）是早产最常见的潜在原因之一。然而，很少有流行病学研究，这种产科并发症。作者研究了产妇吸烟和咖啡消费的关系，早产胎膜早破和自发性早产不复杂的胎膜早破（早产NONPROM）在一个大的横截面数据库。1977-1980年在波士顿妇女医院分娩的307例早产胎膜早破和488例早产非胎膜早破病例与随机选择的2,252例在该医院足月分娩的妇女进行了比较。采用多元逻辑回归技术推导调整后优势比（OR）和95%置信区间（Cl）的最大似然估计值。在调整混杂因素后，与非吸烟者相比，报告在妊娠期间吸烟的妇女发生早产胎膜早破的相对危险度为1.6（95%CI 1.1-2.4）。然而，未观察到每天吸烟数量与早产胎膜早破风险之间的梯度。在妊娠早期，每天喝三杯或更多咖啡的妇女发生胎膜早破的风险是喝两杯或更少咖啡的妇女的2.2倍（95%CI 1.5-3.3）。在咖啡饮用者中，有证据表明，随着咖啡消耗量的增加，早产胎膜早破的风险呈线性趋势。每天消耗三杯或更多杯咖啡与早产非胎膜早破的发生没有那么强的相关性（调整OR = 1.4，95%CI 1.0-1.9）.Am J Epidemiol 1992，135;895-903。
Premature (prior to 37 completed weeks of gestation) rupture of the membranes (preterm PROM) is one of the most common underlying causes of preterm delivery. However, there have been few epidemiologic studies of this obstetric complication The authors studied the relation of maternal cigarette smoking and coffee consumption to both preterm PROM and spontaneous preterm labor not complicated by premature rupture of the membranes (preterm NONPROM) in a large cross-sectional data base. The 307 preterm PROM and 488 preterm NONPROM cases who delivered during 1977–1980 at the Boston Hospital for Women were compared with 2,252 randomly selected women who delivered at term at that institution. Multiple logistic regression techniques were used to derive maximum likelihood estimates of adjusted odds ratios (OR) and 95% confidence intervals (Cl). After confounders had been adjusted for, the relative risk of preterm PROM for women who reported ever having smoked during pregnancy, as compared with nonsmokers, was 1.6 (95% Cl 1.1–2.4). However, no gradient between the the number of cigarettes smoked per day and the risk of preterm PROM was observed Similar results were observed for preterm NONPROM. Women who consumed three or more cups of coffee daily during the first trimester had a 2.2-fold greater risk of preterm PROM than did women who drank two or fewer cups (95% Cl 1.5–3.3). Among coffee drinkers, there was some evidence of a linear trend in the risk of preterm PROM as coffee consumption increased Consumption of three or more cups of coffee per day was less strongly associated with the occurrence of preterm NONPROM (adjusted OR = 1.4, 95% Cl 1.0–1.9).Am J Epidemiol1992,135;895–903.