INTESTINAL INTRAEPITHELIAL LYMPHOCYTES ARE A DISTINCT SET OF GAMMA-DELTA-T-CELLS
INTESTINAL INTRAEPITHELIAL LYMPHOCYTES ARE A DISTINCT SET OF GAMMA-DELTA-T-CELLS
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DOI：
10.1038/336479a0
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发表时间：
1988-12-01
期刊：
影响因子：
64.8
通讯作者：
TONEGAWA, S
中科院分区：
文献类型：
--
作者：
BONNEVILLE, M;JANEWAY, CA;TONEGAWA, S
淋巴细胞根据其在细胞表面的抗原受体最可靠地进行细分。T细胞有三种亚型：B细胞表面免疫球蛋白并产生抗体，CD_4~+T细胞结合CD_3MHC(3种主要组织相容性复合体抗原受体)，CD_8~+T细胞与CD_3αβ(与I类αβ分子相关的抗原受体)结合。这些T细胞负责已知形式的细胞免疫。第三个重排T细胞特异性基因γ(参考文献1和2)的发现揭示了一类新的T细胞的存在，该T细胞具有一种新的受体类型--CD3CD3γδ(参考文献3-7)。到目前为止，携带这种受体的细胞的功能和特异性都还没有确定。因为γδT细胞是表皮8-9的主要淋巴细胞，所以有人认为这种细胞在所有上皮的监测中可能是重要的。我们已经从小鼠小肠11-13分离出上皮内淋巴细胞，并表明它们主要或唯一地表达CD3γδ受体。与表皮淋巴细胞不同的是，这些细胞也表达CD8，它们使用不同的V-γ基因来形成它们的受体。这有力地表明，γδT细胞以一种非常特殊的方式与上皮细胞结合，在那里它们可能介导着它们的功能。
Lymphocytes are most reliably subdivided on the basis of their receptors for antigen at the cell surface. Three subtypes of lym-phocytes are well defined: B cells that bear surface immunoglobulin and make antibody, CD4+T cells with CD3 αβ(3 receptors specific for antigen associated with class II major histocompatibility com-plex molecules, and CD8+T cells with CD3 αβ( receptors specific for antigen associated with class I MHC molecules. These T cells are responsible for known forms of cell-mediated immunity. The discovery of a third rearranging T-cell specific gene called γ(refs1 and 2) has revealed the presence of a new class of T cells bearing a new receptor type, CD3 γδ (refs 3–7). To date, neither the function nor the specificity of cells bearing this receptor has been determined. Because γδ T cells are the main lymphocyte of epidermis8–9, it was proposed that such cells could be important in surveillance of all epithelia10. We have isolated intraepithelial lymphocytes from murine small intestine11–13, and shown that they predominantly or exclusively express CD3 γδ receptors. Unlike the epidermal lymphocytes, these cells also express CD8, and they use a differentVγgene to form their receptor. This strongly suggests that γδ T cells home in a very specific manner to epithelia, where they presumably mediate their function.