Origin and evolution of flavivirus 5′UTRs and panhandles:: Trans-terminal duplications?
Origin and evolution of flavivirus 5′UTRs and panhandles:: Trans-terminal duplications?
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DOI：
10.1016/j.virol.2007.04.011
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发表时间：
2007-09-15
期刊：
影响因子：
3.7
通讯作者：
Gould, E. A.
中科院分区：
文献类型：
--
作者：
Gritsun, T. S.;Gould, E. A.
黄病毒复制由形成dsRNA环化茎或柄的5 '-和3'-末端的互补ssRNA序列之间的相互作用介导，其在蚊媒、蜱媒、非载体和未分类的黄病毒中的长度、序列和特定位置不同。在这份手稿中，我们手动比对黄病毒5 'UTR和相邻的衣壳基因，并揭示了显着更多的同源性比迄今已确定的。比对分析显示，柄状结构代表了一个长环化结构域的进化残留物，该结构域可能是通过UTR末端之一的复制而出现的。(c)2007年爱思唯尔公司All rights reserved.
Flavivirus replication is mediated by interactions between complementary ssRNA sequences of the 5'- and 3'-termini that form dsRNA cyclisation stems or panhandles, varying in length, sequence and specific location in the mosquito-bome, tick-borne, non-vectored and non-classified flaviviruses. In this manuscript we manually aligned the flavivirus 5'UTRs and adjacent capsid genes and revealed significantly more homology than has hitherto been identified. Analysis of the alignments revealed that the panhandles represent evolutionary remnants of a long cyclisation domain that probably emerged through duplication of one of the UTR termini. (c) 2007 Elsevier Inc. All rights reserved.