Ligand-Free RuCl3-Catalyzed Alkylation of Methylazaarenes with Alcohols
Ligand-Free RuCl3-Catalyzed Alkylation of Methylazaarenes with Alcohols
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无配体 RuCl3 催化甲基氮杂芳烃与醇的烷基化
DOI：
10.1021/acs.joc.6b03095
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发表时间：
2017-04-21
影响因子：
3.6
通讯作者：
Lang, Jian-Ping
中科院分区：
文献类型：
--
作者：
Peng, Tong-Yu;Li, Hong-Xi;Lang, Jian-Ping
RuCl_3能有效地催化甲基喹啉、甲基吡啶、2-甲基苯并恶唑和2-甲基喹喔啉与烷基醇或芳基醇的烷基化反应。反应机理研究表明，烷基化反应经历了转移氢化、羟醛缩合和氢化反应的分步过程。
RuCl3 efficiently catalyzes the alkylation of methylquinolines, methylpyridines, 2-methyl-benzooxazoles, and 2-methyl-quinoxa-lines with alkyl- or aryl-alcohols as alkylating agents. This synthetically useful and atom economical transformationdoes not require additional ligands.The mechanistic study indicated the alkylation reaction underwent a stepwise transfer hydrogenation, aldol condensation, and hydrogenation reaction pathway.