Chiral Silver Alkoxide Catalyzed Asymmetric Aldol Reaction of Alkenyl Esters with Isatins
Chiral Silver Alkoxide Catalyzed Asymmetric Aldol Reaction of Alkenyl Esters with Isatins
复制标题
手性醇银催化烯基酯与靛红的不对称羟醛反应
DOI：
10.1055/a-1479-4694
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发表时间：
2021
期刊：
影响因子：
2
通讯作者：
A. Yanagisawa and A. Kawada
中科院分区：
文献类型：
--
作者：
Tanaka Susumu;Konishi Masafumi;Imoto Hiroaki;Nakamura Yuma;Ishida Masatoshi;Furuta Hiroyuki;Naka Kensuke;川幡正俊，富永昌英，小松亮太，兵頭直，山口健太郎;A. Yanagisawa and A. Kawada
以DM-BINAP·AgOTf为手性预催化剂，N，N-二异丙基乙胺为碱催化剂，在甲醇或2，2，2-三氟乙醇存在下，实现了烯基酯与靛红的不对称羟醛缩合反应.光学活性的3-烷基化3-羟基-2-羟吲哚具有高达98%ee的非对映选择性地获得中到高产率，不仅从环状烯基酯，而且从无环的通过原位生成的手性银烯醇化物。
A catalytic enantioselective aldol reaction of alkenyl esters with isatins was achieved using a DM-BINAP·AgOTf complex as the chiral precatalyst andN,N-diisopropylethylamine as the base precatalyst in the presence of methanol or 2,2,2-trifluoroethanol. Optically active 3-alkylated 3-hydroxy-2-oxindoles having up to 98% ee were diastereoselectively obtained in moderate to high yields not only from cyclic alkenyl esters but also from acyclic ones through the in situ generated chiral silver enolates.
酸酐的反应-III
影响因子：
2.1
作者：
J. Libman;M. Sprechert;Y. Mazur
通讯作者：
Y. Mazur