Elevated nitrite in breath condensates of children with respiratory disease
Elevated nitrite in breath condensates of children with respiratory disease
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DOI：
10.1183/09031936.02.00101202
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发表时间：
2002-03-01
影响因子：
24.3
通讯作者：
Hall, GL
中科院分区：
文献类型：
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作者：
Formanek, W;Inci, D;Hall, GL
本研究的目的是确定健康儿童和患有哮喘、囊性纤维化（CF）和非哮喘性发作性咳嗽的儿童的呼出气冷凝物中亚硝酸盐的差异，收集了66名儿童（男43名：女23名，年龄3.1-16岁）的呼出气冷凝物，其中包括29名哮喘患者，12名临床稳定的CF患者，12名咳嗽但无哮喘的儿童和13名健康志愿者。收集的冷凝液使用Griess反应进行比色分析，以确定亚硝酸盐浓度。（c）小提琴; 2.02：0.43-6.37 μ M）或哮喘（2.10：0.63-5.45 μ M）的亚硝酸盐水平显著高于健康受试者（0.41：0.13-1.83 μ M; p
The aim of the study was to determine the differences in nitrite, in the exhaled breath condensates of healthy children and those children with asthma, cystic fibrosis (CF) and nonasthmatic, episodic cough.Breath condensates were obtained from 66 children (43 males:23 females, 3.1-16 yrs) and included 29 asthmatics, 12 clinically stable CF patients, 12 children with cough but not asthma and 13 healthy volunteers. The collected condensate was assayed colourimetrically using the Griess reaction to determine nitrite concentrations.Patients with CF (median: 5-95%. percentiles; 2.02: 0.43-6.37 muM) or asthma (2.10: 0.63-5.45 muM) had significantly higher levels of nitrite compared to healthy subjects (0.41: 0.13-1.83 muM; p