RAT SELF ADMINISTRATION OF ETHANOL - ENHANCEMENT BY DARKNESS AND EXOGENOUS MELATONIN
RAT SELF ADMINISTRATION OF ETHANOL - ENHANCEMENT BY DARKNESS AND EXOGENOUS MELATONIN
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DOI：
10.1016/0031-9384(80)90287-5
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发表时间：
1980-01-01
影响因子：
2.9
通讯作者：
ARMSTRONG, S
中科院分区：
文献类型：
--
作者：
SMITH, D;OEI, TPS;ARMSTRONG, S
使用FT（固定时间）60时间表，在12：12光-暗循环的黑暗阶段测试的100%自由喂养的大鼠接受训练，以自行静脉注射乙醇。效果是剂量依赖性的，通过输注次数测量，20%乙醇是首选剂量。每天给予1.5毫克/公斤褪黑激素显着增加乙醇自我注射在黑暗中，但不是在光。一天中的测试和/或给药时间可能是自我给药研究中的一个重要变量。在黑暗中进行测试可以消除在诱导乙醇自我给药时减轻体重的需要。
Using a FT (fixed time) 60 schedule, rats on 100% free-feeding tested in the dark phase of a 12:12 light-dark cycle were trained to self-administer ethanol i.v. The effect was dose-dependent, with 20% ethanol being the preferred dose as measured by the number of infusions. Daily administration of 1.5 mg/kg melatonin significantly increased ethanol self-injection in the dark but not in the light. The time of day of testing and/or drug administration may be an important variable in studies on self-administration of drugs. Testing in the dark may eliminate the need for reducing body weight when inducing self-administration of ethanol.