Polarization-sensitive optical coherence elastography
Polarization-sensitive optical coherence elastography
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DOI：
10.1364/boe.10.005162
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发表时间：
2019-10-01
影响因子：
3.4
通讯作者：
Yasuno, Yoshiaki
中科院分区：
文献类型：
--
作者：
Miyazawa, Arata;Makita, Shuichi;Yasuno, Yoshiaki
偏振敏感光学相干弹性成像(PS-OCE)是为了提高组织分辨能力而发展起来的。它集成了基于Jones矩阵的PS-OCT(PS-OCT)和压缩OCE。该方法同时测量OCT强度、衰减系数、双折射和组织压缩引起的微结构变形(MSD)。用PS-OCE和组织学成像技术对体外培养的猪主动脉和食道组织进行观察。PS-OCE测量的组织特性显示为横断面图像和三维(3-D)深度-轨迹图。在该轨迹图中，计算了每个深度的平均衰减系数、双折射和MSD，并将深度方向的轨迹绘制在这三个特性的三维特征空间中。组织学图像中的组织边界与深度轨迹拐点相对应。三种组织特性的直方图分析和t分布随机邻近嵌入(t-SNE)可视化表明，PS-OCE测量为区分猪食道组织提供了足够的信息。(C)OSA开放获取出版协议条款下的2019年美国光学学会
Polarization-sensitive optical coherence elastography (PS-OCE) is developed for improved tissue discrimination. It integrates Jones matrix-based PS-optical coherence tomography (PS-OCT) with compression OCE. The method simultaneously measures the OCT intensity, attenuation coefficient, birefringence, and microstructural deformation (MSD) induced by tissue compression. Ex vivo porcine aorta and esophagus tissues were investigated by PS-OCE and histological imaging. The tissue properties measured by PS-OCE are shown as cross-sectional images and a three-dimensional (3-D) depth-trajectory plot. In this trajectory plot, the average attenuation coefficient, birefringence, and MSD were computed at each depth, and the trajectory in the depth direction was plotted in a 3-D feature space of these three properties. The tissue boundaries in a histological image corresponded with the depth-trajectory inflection points. Histogram analysis and t-distributed stochastic neighbour embedding (t-SNE) visualization of the three tissue properties indicated that the PS-OCE measurements provide sufficient information to discriminate porcine esophagus tissues. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement