Effects of surgical and pharmacological adrenalectomy on the initiation and maintenance of intravenous cocaine self-administration in rats
Effects of surgical and pharmacological adrenalectomy on the initiation and maintenance of intravenous cocaine self-administration in rats
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DOI：
10.1016/0006-8993(96)00206-5
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发表时间：
1996-05-25
期刊：
影响因子：
2.9
通讯作者：
Guerin, GF
中科院分区：
文献类型：
--
作者：
Goeders, NE;Guerin, GF
先前的研究表明，下丘脑-垂体-肾上腺（HPA）轴可能参与精神兴奋剂强化。特别是，我们已经发现了显着的相关性之间的电电击引起的血浆皮质酮的增加和收购，或缺乏，静脉注射可卡因销售管理的大鼠。这里提出的实验旨在进一步确定皮质酮在可卡因强化大鼠中的作用，通过手术和药物肾上腺切除术降低激素的血浆水平。双侧肾上腺切除术完全消除了在广泛剂量范围内（0.03125至1.0 mg/kg/输注）静脉内可卡因自我给药的获得，而不影响食物维持反应。通过向大鼠饮用水中加入皮质酮（100 μ g/ml），可部分逆转这种自我给药的抑制。在另一组大鼠中，用甲吡酮（它阻断皮质酮的合成）预处理，导致正在进行的可卡因自我给药的剂量相关减少。这些数据表明，皮质酮不仅是重要的，但也可能是必要的收购和维护可卡因强化大鼠。
Previous research has suggested the potential involvement of the hypothalamic-pituitary-adrenal (HPA) axis in psychostimulant reinforcement. In particular, we have found significant correlations between electric footshock-induced increases in plasma corticosterone and the acquisition, or lack thereof, of intravenous cocaine sell-administration in rats. The experiments presented here were designed to further determine the role for corticosterone in cocaine reinforcement in rats by decreasing plasma levels of the hormone with surgical and pharmacological adrenalectomies. Bilateral adrenalectomy completely abolished the acquisition of intravenous cocaine self-administration over a wide range of doses (0.03125 to 1.0 mg/kg/infusion) without affecting food maintained responding. This suppression of self-administration was partially reversed by adding corticosterone (100 mu g/ml) to the rats' drinking water. In another group of rats, pretreatment with metyrapone, which blocks the synthesis of corticosterone, resulted in dose-related decreases in ongoing cocaine self-administration. These data suggest that corticosterone is not only important, but may also be necessary for both the acquisition and maintenance of cocaine reinforcement in rats.