A GENE OUTSIDE THE HUMAN MHC RELATED TO CLASSICAL HLA CLASS-I GENES
A GENE OUTSIDE THE HUMAN MHC RELATED TO CLASSICAL HLA CLASS-I GENES
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DOI：
10.1126/science.7624800
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发表时间：
1995-08-04
期刊：
影响因子：
56.9
通讯作者：
KUROSAWA, Y
中科院分区：
文献类型：
--
作者：
HASHIMOTO, K;HIRAI, M;KUROSAWA, Y
主要组织相容性复合体（MHC）I类分子通过呈递抗原肽至T淋巴细胞，在人类免疫系统中发挥重要作用。知识是有限的人类MHC I类相关分子的进化历史。一个表达的I类基因，MRI，现在已被确定在人类染色体1q25上，在MHC之外。与其他已知的人类异源I类基因相比，MR1编码的肽结合域与6号染色体上的人类白细胞抗原（HLA）I类基因和非哺乳动物经典MHC I类基因编码的肽结合域相似。因此，该基因可能有助于理解MHC的进化。
By presenting antigenic peptides to T lymphocytes, major histocompatibility complex (MHC) class I molecules play important roles in the human immune system. Knowledge is limited on the evolutionary history of human MHC class I-related molecules. An expressed class I gene, MRI, has now been identified on human chromosome 1q25, outside the MHC. In contrast to other known human divergent class I genes, MR1 encodes peptide-binding domains similar to those encoded by human leukocyte antigen (HLA) class I genes on chromosome 6 and by nonmammalian classical MHC class I genes. This gene may thus contribute to understanding the evolution of the MHC.