Pathogenesis of systemic hypertension and glomerular injury in the spontaneously hypertensive rat.
Pathogenesis of systemic hypertension and glomerular injury in the spontaneously hypertensive rat.
复制标题
自发性高血压大鼠全身性高血压和肾小球损伤的发病机制。
DOI：
10.1016/0002-9149(87)90459-0
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Dworkin,LD
中科院分区：
文献类型：
--
作者：
Martínez-Maldonado,M;Rodríguez-Sargent,C;Cangiano,JL;Dworkin,LD
Weanling and young spontaneously hypertensive rats (SHRs) demonstrate higher plasma renin activity and plasma aldosterone concentration than age-matched normotensive Wistar-Kyoto (WKY) control rats. In addition, this age group exhibits a salt-retaining tendency not seen in WKYs. Nevertheless, when they reach adulthood, these differences between SHRs and WKYs are all but abolished, yet hypertension persists in SHRs. The possible mechanisms leading to these changes in SHRs and to the differences seen with advancing age are discussed. Results of micropuncture studies that help elucidate the glomerular hemodynamic adaptations to elevation in systemic blood pressure in young SHRs are also presented. Evidence is advanced suggesting that increased intraglomerular pressure is responsible for the histologic lesions characteristic of untreated severe hypertension. The salutary effects of treatment with vasodilator drugs that reduce intraglomerular pressure are emphasized.
