CD146‐mediated acquisition of stemness phenotype enhances tumour invasion and metastasis after EGFR‐TKI resistance in lung cancer
CD146‐mediated acquisition of stemness phenotype enhances tumour invasion and metastasis after EGFR‐TKI resistance in lung cancer
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DOI：
10.1111/crj.12976
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发表时间：
2019-01
期刊：
影响因子：
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通讯作者：
Fan Zhang;Jia Wang;Xiaobo Wang;Nan Wei;Haiyang Liu;Xiaoju Zhang
中科院分区：
文献类型：
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作者：
Fan Zhang;Jia Wang;Xiaobo Wang;Nan Wei;Haiyang Liu;Xiaoju Zhang
肿瘤对 EGFR-TKI 产生耐药性后更容易发生转移。 CD146是一种多功能分子，与肿瘤侵袭和转移有关；然而，其在肺癌中的作用尚未明确。
Tumours are more likely to metastasize after the development of resistance to EGFR‐TKIs. CD146 is a multifunctional molecule and is implicated in tumour invasion and metastasis; however, its role in lung cancer has not been clearly established.