Interleukin-4, a T-helper 2 cell cytokine, is associated with the remission of periodontal disease
Interleukin-4, a T-helper 2 cell cytokine, is associated with the remission of periodontal disease
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DOI：
10.1111/j.1600-0765.2007.01079.x
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发表时间：
2008-12-01
影响因子：
3.5
通讯作者：
Swati, P. P.
中科院分区：
文献类型：
--
作者：
Pradeep, A. R.;Roopa, Y.;Swati, P. P.
白细胞介素-4（IL-4）主要由辅助性T细胞2分泌，是B淋巴细胞生长和增殖的关键细胞因子。先前的研究已经证明，IL-4由于其有效抑制单核细胞/巨噬细胞产生促炎细胞因子如肿瘤坏死因子-α（TNF-α）、IL-1 α、IL-1 β、IL-6和IL-8而具有抗炎作用。本研究的目的是评估临床参数与炎症牙龈和牙周炎部位龈沟液中IL-4浓度之间的关系，并随后对牙周炎部位进行治疗。总共60名受试者根据牙龈指数（GI）、袋探深度和临床附着丧失（CAL）分为三组：健康组（第1组）、牙龈炎组（第2组）和慢性牙周炎组（第3组）。第四组（第4组）由第3组的20名受试者组成，治疗后6-8周（即刮治和根面平整）。使用酶免疫测定法对从每位患者收集的牙龈沟液样本中的IL-4进行定量。第1组的IL-4平均浓度最高（99.39 +/- 49.33 pg/mL），第3组的IL-4平均浓度最低（15.78 +/- 21.92 pg/mL）。第2组（64.34 ± 39.56 pg/mL）和第4组（68.92 ± 42.85 pg/mL）的平均IL-4浓度介于健康受试者和牙周炎受试者之间。因此，我们认为，2型辅助性T细胞因子，如IL-4所代表的，与牙周病的缓解或改善。
Interleukin-4 (IL-4), secreted mainly by T-helper 2 cells, is a key cytokine for the growth and proliferation of B lymphocytes. Previous studies have proved that IL-4 has an anti-inflammatory effect owing to its efficient inhibition of the production of proinflammatory cytokines such as tumour necrosis factor-alpha (TNF-alpha), IL-1 alpha, IL-1 beta, IL-6 and IL-8 by monocytes/macrophages. The aim of the present study was to assess the relation between clinical parameters and concentrations of IL-4 within gingival crevicular fluid from inflamed gingiva and periodontitis sites and, subsequently, after treatment of the periodontitis sites.A total of 60 subjects were divided into three groups based on gingival index (GI), pocket probing depth and clinical attachment loss (CAL): healthy (group 1), gingivitis (group 2) and chronic periodontitis (group 3). A fourth group (group 4) consisted of 20 subjects from group 3, 6-8 weeks after treatment (i.e. scaling and root planing). Gingival crevicular fluid samples collected from each patient were quantified for IL-4 using the enzymatic immunometric assay.The highest mean concentration of IL-4 was obtained for group 1 (99.39 +/- 49.33 pg/mL) and the lowest mean concentration of IL-4 was obtained for group 3 (15.78 +/- 21.92 pg/mL). The mean IL-4 concentrations for group 2 (64.34 +/- 39.56 pg/mL) and group 4 (68.92 +/- 42.85 pg/mL) were intermediate between the levels in healthy subjects and periodontitis subjects.The mean concentration of IL-4 decreased from periodontal health to disease. Thus, we suggest that type 2 helper T cell cytokine, as represented by IL-4, was associated with the remission or improvement of periodontal disease.