Assessment of dementia in patients with multiple system atrophy
Assessment of dementia in patients with multiple system atrophy
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DOI：
10.1111/j.1468-1331.2009.02544.x
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发表时间：
2009-05-01
影响因子：
5.1
通讯作者：
Nakashima, K.
中科院分区：
文献类型：
--
作者：
Kitayama, M.;Wada-Isoe, K.;Nakashima, K.
我们调查了多系统萎缩（MSA）患者中的痴呆，以描述这些患者中损害的患病率和性质。1996年4月至2006年12月期间，我们研究了58例MSA患者。在58例患者中，10例被诊断为痴呆。痴呆患者和非痴呆患者在发病年龄、性别、病程或小脑功能障碍的严重程度方面没有显著差异。与非痴呆患者相比，痴呆患者的I-123-间碘苯胍（MIBG）心脏动脉造影获得的早期和延迟心脏与纵隔（H/M）比值显著降低。在10名痴呆症患者中，发现3名在运动症状发作之前有认知能力下降。白色病变在这些患者中是明显的，而额叶萎缩是突出的患者，其认知能力下降之前的运动symptoms.Dementia在MSA患者可能比以前认为的更常见，此外，我们推测，痴呆的临床特征在这些患者可能是异质性的。
We investigated dementia in patients with multiple system atrophy (MSA) in order to characterize the prevalence and nature of impairments in these patients.Fifty-eight MSA patients were recruited in our institution between April 1996 and December 2006 and investigated.Of 58 patients, 10 were diagnosed with dementia. There were no significant differences in age at onset, gender, duration of disease, or severity of cerebellar dysfunction between patients with and without dementia. The early and delayed heart to mediastinum (H/M) ratios obtained with I-123-metaidobenylguanidine (MIBG) cardiac scintigraphy were significantly decreased in patients with dementia compared with those without dementia. Of the 10 patients with dementia, three were found to have cognitive decline that preceded onset of motor symptoms. White matter lesions were evident in these patients, whilst frontal atrophy was prominent in patients whose cognitive decline was preceded by onset of motor symptoms.Dementia in patients with MSA may be more common than previously thought, furthermore, we speculate that clinical features of dementia in these patients might be heterogeneous.