The impact of occipital lobe cortical thickness on cognitive task performance: An investigation in Huntington's Disease
The impact of occipital lobe cortical thickness on cognitive task performance: An investigation in Huntington's Disease
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DOI：
10.1016/j.neuropsychologia.2015.10.033
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发表时间：
2015-12-01
期刊：
影响因子：
2.6
通讯作者：
Scahill, Rachael I.
中科院分区：
文献类型：
--
作者：
Johnson, Eileanoir B.;Rees, Elin M.;Scahill, Rachael I.
研究背景：枕叶是脑内重要的视觉加工区域。在亨廷顿氏病（HD）枕叶早期神经改变的一致发现之后，我们检查了与对照组相比，表现前（preHD）和早期HD组枕叶四个区域的皮质厚度。研究了基因阳性个体的皮质厚度与六项认知任务（每项任务都有视觉成分）的表现之间的关联。此外，在基因阳性的参与者和一个非视觉运动task.Methods：皮质厚度之间的关联也检查了T1加权3T MR数据集从对照组（N = 97），前HD（N = 109）和HD（N = 69）从TRACK-HD研究使用FreeSurfer确定。回归模型进行了拟合，以评估组间差异的皮质厚度，并在一个子集的基因阳性的参与者（N = 141）的认知任务，运动任务和枕叶厚度的性能之间的关系进行了检查。结果：枕叶皮质厚度在preHD和早期HD参与者相比，控制组减少。在六项认知任务中的五项中，发现皮质厚度减少与表现较差之间存在区域特异性关联，其中枕外侧和舌侧区域的关联最强。未发现与楔叶相关。非视觉运动任务与任何区域的厚度无关。结论：本研究中发现的异质性关联模式表明，枕叶厚度对认知产生负面影响，但仅在与相对高级的视觉处理相关的区域（例如，外侧枕、舌区域），而不是在基本的视觉处理区域如楔叶中。我们的研究结果表明，第一次，枕叶萎缩的功能影响，强调在最近的研究在HD。(C)2015爱思唯尔有限公司版权所有。
Background: The occipital lobe is an important visual processing region of the brain. Following consistent findings of early neural changes in the occipital lobe in Huntington's Disease (HD), we examined cortical thickness across four occipital regions in premanifest (preHD) and early HD groups compared with controls. Associations between cortical thickness in gene positive individuals and performance on six cognitive tasks, each with a visual component, were examined. In addition, the association between cortical thickness in gene positive participants and one non-visual motor task was also examined for comparison.Methods: Cortical thickness was determined using FreeSurfer on T1-weighted 3T MR datasets from controls (N=97), preHD (N=109) and HD (N=69) from the TRACK-HD study. Regression models were fitted to assess between-group differences in cortical thickness, and relationships between performance on the cognitive tasks, the motor task and occipital thickness were examined in a subset of gene-positive participants (N=141).Results: Thickness of the occipital cortex in preHD and early HD participants was reduced compared with controls. Regionally-specific associations between reduced cortical thickness and poorer performance were found for five of the six cognitive tasks, with the strongest associations in lateral occipital and lingual regions. No associations were found with the cuneus. The non-visual motor task was not associated with thickness of any region.Conclusions: The heterogeneous pattern of associations found in the present study suggests that occipital thickness negatively impacts cognition, but only in regions that are linked to relatively advanced visual processing (e.g., lateral occipital, lingual regions), rather than in basic visual processing regions such as the cuneus. Our results show, for the first time, the functional implications of occipital atrophy highlighted in recent studies in HD. (C) 2015 Elsevier Ltd. All rights reserved.