Sex Differences in Variability of Brain Structure Across the Lifespan
Sex Differences in Variability of Brain Structure Across the Lifespan
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DOI：
10.1093/cercor/bhaa123
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发表时间：
2020-10-01
期刊：
影响因子：
3.7
通讯作者：
Voineskos, Aristotle N.
中科院分区：
文献类型：
--
作者：
Forde, Natalie J.;Jeyachandra, Jerrold;Voineskos, Aristotle N.
几种脑部疾病在发病、表现和患病率方面表现出性别差异。增加对整个生命周期中基于性别的变异性差异的神经生物学的理解，可以深入了解疾病的脆弱性和恢复力。在n = 3069参与者中，从8岁到95岁，我们发现男性与女性相比，在皮质表面积和离散脑区的全球和皮质下体积的广泛更大的变异性。相比之下，雄性和雌性的皮质厚度变化相似。这些发现得到了解释结构协方差的多变量分析的支持，并且在整个生命周期内存在并稳定。此外，我们还研究了不同性别的大脑区域之间的差异。我们在神经影像学指标中发现了显着的年龄与性别的相互作用，即在生命早期，男性与女性相比，大脑皮层区域的变异性降低，而在生命晚期，这种情况则相反。总的来说，我们的研究结果更大的区域变异性，但在男性的早期生活中较少的区域变异性可能有助于我们理解基于性别的神经发育障碍的风险。相反，我们在晚年的发现可能为痴呆症提供了一个潜在的基于性别的风险机制。
Several brain disorders exhibit sex differences in onset, presentation, and prevalence. Increased understanding of the neurobiology of sex-based differences in variability across the lifespan can provide insight into both disease vulnerability and resilience. In n = 3069 participants, from 8 to 95 years of age, we found widespread greater variability in males compared with females in cortical surface area and global and subcortical volumes for discrete brain regions. In contrast, variance in cortical thickness was similar for males and females. These findings were supported by multivariate analysis accounting for structural covariance, and present and stable across the lifespan. Additionally, we examined variability among brain regions by sex. We found significant age-by-sex interactions across neuroimaging metrics, whereby in very early life males had reduced among-region variability compared with females, while in very late life this was reversed. Overall, our findings of greater regional variability, but less among-region variability in males in early life may aid our understanding of sex-based risk for neurodevelopmental disorders. In contrast, our findings in late life may provide a potential sex-based risk mechanism for dementia.