Urinary Phytoestrogen Levels and Frailty in Older American Women of the National Health and Nutrition Examination Survey (NHANES) 1999-2002: A Cross-Sectional Study
Urinary Phytoestrogen Levels and Frailty in Older American Women of the National Health and Nutrition Examination Survey (NHANES) 1999-2002: A Cross-Sectional Study
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DOI：
10.1159/000356453
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发表时间：
2013-01-01
影响因子：
3.9
通讯作者：
Rohrmann, Sabine
中科院分区：
文献类型：
--
作者：
Eichholzer, Monika;Richard, Aline;Rohrmann, Sabine
背景/目的：衰老过程中各种激素的缺乏和/或炎症状态的加剧可能与虚弱的发展存在因果关系。植物雌激素作为弱雌激素、抗氧化剂和抗炎剂可能会抵消这一过程。方法：在一项包括两个周期的国家健康和营养检查调查（NHANES，即 1999-2002 年）的横断面研究中，使用逻辑回归分析了 600 名 50 岁或以上女性（中位年龄 66.5 岁）尿异黄酮和木脂素浓度与虚弱之间的关系。参与者被分为“虚弱”（满足 5 个虚弱标准中的 3 个或更多）、“脆弱”（满足 1 或 2 个标准）或“健壮”（不满足任何标准）。百分之四的人身体虚弱。结果：对于所有考虑的植物雌激素，未经调整的 OR 均低于 1，但除了与 O-去甲基安哥拉素 (O-DMA) 相关外，一般不具有统计学显着性（OR = 0.76；95% CI 0.61-0.92）。多变量分析并没有削弱这一发现（OR = 0.74；95% CI 0.61-0.90）。结论：对植物雌激素与虚弱之间关系的首次分析揭示了女性尿液中 O-DMA 水平与虚弱之间呈负相关。然而，体弱妇女的数量很少。尽管这一发现可能令人困惑或有偏见，但似乎值得加强对 O-DMA 潜在预防作用的研究。 (C) 2013 S. Karger AG，巴塞尔
Background/Aims: A deficit of various hormones during the process of aging and/or a heightened inflammatory state may be causally linked to the development of frailty. Phytoestrogens as weak estrogens, antioxidants, and anti-inflammatory agents may counteract this process. Methods: In a cross-sectional study including two cycles of the National Health and Nutrition Examination Survey (NHANES, i.e. 1999-2002), logistic regression was used to analyze the association between urinary concentrations of isoflavones and lignans and frailty in 600 females aged 50 years or older (median age 66.5 years). Participants were classified as 'frail' (meeting 3 or more of the 5 frailty criteria), 'prefrail' (meeting 1 or 2 of the criteria), or 'robust' (meeting none of the criteria). Four percent were frail. Results: For all of the phytoestrogens considered, the unadjusted OR were lower than 1 but generally not statistically significant aside from the association with O-desmethylangolensin (O-DMA) (OR = 0.76; 95% CI 0.61-0.92). Multivariate analysis did not attenuate this finding (OR = 0.74; 95% CI 0.61-0.90). Conclusions: This first analysis of the relationship between phytoestrogens and frailty revealed an inverse association between urinary O-DMA levels and frailty in women. However, the number of frail women was low. Although this finding may be confounded or biased, it seems worthwhile to intensify research on the potential preventive effects of O-DMA. (C) 2013 S. Karger AG, Basel